…we can begin to tell a coherent story. Stress and inflammation produce derivatives of cortisol and cholesterol, which trigger misfolding in A-beta proteins. This, in turn, overwhelms the cells’ quality-assurance mechanism and results in growing numbers of insoluble proteins, which aggregate in plaques and tangles. And this blocks the transport of vital ingredients around brain cells, which causes the cells to die.
Somewhere along this chain, there is a link, we must hope, that can be attacked by medication””to prevent inflammation, discourage ozone reactions, encourage the refolding apparatus, improve protein solubility or boost the plaque-removal mechanism.