{"id":121694,"date":"2023-06-30T06:59:48","date_gmt":"2023-06-30T10:59:48","guid":{"rendered":"http:\/\/kendallharmon.net\/?p=121694"},"modified":"2023-06-30T15:01:38","modified_gmt":"2023-06-30T19:01:38","slug":"bi-researchers-uncover-new-crispr-like-system-in-animals-that-can-edit-the-human-genome","status":"publish","type":"post","link":"https:\/\/kendallharmon.net\/?p=121694","title":{"rendered":"(BI) Researchers uncover new CRISPR-like system in animals that can edit the human genome"},"content":{"rendered":"<p>A team of researchers led by\u00a0<a href=\"https:\/\/www.broadinstitute.org\/node\/7577\">Feng Zhang<\/a>\u00a0at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes \u2014 organisms that include fungi, plants, and animals.<\/p>\n<p>In a study in\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06356-2\" target=\"_blank\" rel=\"noopener\" aria-label=\"Nature - opens in new tab\" data-uw-rm-ext-link=\"\"><em>Nature<\/em><\/a>, the team describes how the system is based on a protein called Fanzor. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. The compact Fanzor systems have the potential to be more easily delivered to cells and tissues as therapeutics than CRISPR\/Cas systems, and further refinements to improve their targeting efficiency could make them a valuable new technology for human genome editing.<\/p>\n<p>CRISPR\/Cas was first discovered in prokaryotes (bacteria and other single-cell organisms that lack nuclei) and scientists including Zhang\u2019s lab have long wondered whether similar systems exist in eukaryotes. The new study demonstrates that RNA-guided DNA-cutting mechanisms are present across all kingdoms of life.<\/p>\n<p><a href=\"https:\/\/www.broadinstitute.org\/news\/researchers-uncover-new-CRISPR-like-system-in-animals-that-can-edit-the-human-genome\">Read it all<\/a>.<\/p>\n<blockquote class=\"twitter-tweet\">\n<p lang=\"en\" dir=\"ltr\">Researchers uncover a new CRISPR-like system in animals that can edit the human genome: The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR\/Cas systems. <a href=\"https:\/\/t.co\/ISGVLtFfnf\">https:\/\/t.co\/ISGVLtFfnf<\/a> <a href=\"https:\/\/t.co\/0Nm1okudit\">pic.twitter.com\/0Nm1okudit<\/a><\/p>\n<p>&mdash; Massachusetts Institute of Technology (MIT) (@MIT) <a href=\"https:\/\/twitter.com\/MIT\/status\/1674811402903515137?ref_src=twsrc%5Etfw\">June 30, 2023<\/a><\/p><\/blockquote>\n<p> <script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of researchers led by\u00a0Feng Zhang\u00a0at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes \u2014 organisms that include fungi, plants, and animals.<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/kendallharmon.net\/?p=121694\">Read more &#8250;<\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":794,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[95],"tags":[],"class_list":["post-121694","post","type-post","status-publish","format-standard","hentry","category-science-technology"],"_links":{"self":[{"href":"https:\/\/kendallharmon.net\/index.php?rest_route=\/wp\/v2\/posts\/121694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kendallharmon.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kendallharmon.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kendallharmon.net\/index.php?rest_route=\/wp\/v2\/users\/794"}],"replies":[{"embeddable":true,"href":"https:\/\/kendallharmon.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=121694"}],"version-history":[{"count":3,"href":"https:\/\/kendallharmon.net\/index.php?rest_route=\/wp\/v2\/posts\/121694\/revisions"}],"predecessor-version":[{"id":121698,"href":"https:\/\/kendallharmon.net\/index.php?rest_route=\/wp\/v2\/posts\/121694\/revisions\/121698"}],"wp:attachment":[{"href":"https:\/\/kendallharmon.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=121694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kendallharmon.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=121694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kendallharmon.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=121694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}