{"id":142636,"date":"2026-01-15T12:28:00","date_gmt":"2026-01-15T17:28:00","guid":{"rendered":"https:\/\/kendallharmon.net\/?p=142636"},"modified":"2026-01-15T18:31:28","modified_gmt":"2026-01-15T23:31:28","slug":"sa-just-one-gene-may-be-responsible-for-over-90-of-alzheimers-cases","status":"publish","type":"post","link":"https:\/\/kendallharmon.net\/?p=142636","title":{"rendered":"(SA) Just One Gene May Be Responsible For Over 90% of Alzheimer’s Cases"},"content":{"rendered":"\n

More than 9 out of 10 Alzheimer’s cases<\/a> could be driven by specific variations in a single gene and the protein it produces, a new study reveals, suggesting that treatments targeting this well-known gene could prevent the disease from developing in the majority of instances.<\/p>\n\n\n\n

The gene in question, APOE<\/em>, has long been associated<\/a> with Alzheimer’s<\/a> risk. What’s new here is the way the different variations of the gene have been analysed and mapped against the chances of developing Alzheimer’s. It turns out that the APOE<\/em> combination we’re born with could be even more important than previously realized.<\/p>\n\n\n\n

Researchers led by a team from University College London (UCL) took a fresh look at the three main variations of the APOE<\/em> gene: \u03b52 (linked to a protective effect<\/a> against cognitive decline), \u03b53 (historically considered the normal or neutral version), and \u03b54 (already known to significantly increase Alzheimer’s risk).<\/p>\n\n\n\n

Read it all<\/a>.<\/p>

Nearly all Alzheimer\u2019s, and half of dementia, is driven by APOE.

A new, large-scale analysis reports that up to 93% of Alzheimer\u2019s cases and 85% of brain amyloid burden are attributable to having an APOE \u03b53\/\u03b54 genotype, and the combined contribution of \u03b53 and \u03b54 to all-cause\u2026 pic.twitter.com\/lbP5NZJ4q7<\/a><\/p>— Dr. Rhonda Patrick (@foundmyfitness) January 9, 2026<\/a><\/blockquote>