(NS) A revolutionary way of targeting tumours could beat even the worst cancers 

Stephen Huff was about to get married when he had a scan to investigate why he had been feeling short of breath. He was a fit 29-year-old who had played professional baseball and never smoked, so he wasn’t expecting the diagnosis: stage 4 lung cancer. “I had multiple spots all in my lungs, my neck, my spine, my liver, my brain – just everywhere,” he says. “I put on a brave front, but deep down I was terrified. I didn’t know if I’d be here in six months.”

Luckily for Huff, his mother, a cancer researcher, encouraged him to get a new kind of test that is quietly revolutionizing treatment. Rather than focusing on the place in the body where the cancer originated – for example, the lungs, bowel or skin – the new approach focuses on genes. The aim is to pinpoint the exact mutation driving the tumor, so it can be switched off with targeted drugs that act like guided missiles.

Through this fresh approach, Huff “hit the lottery” – as his oncologist told him – because it meant he could be treated with a recently approved drug that specifically targeted the genetic alteration driving his cancer. Within weeks, Huff began to feel better. “My first scan showed that basically every tumour site had either shrunk or gone away completely,” he says.

Now, thanks to this precision oncology method, more and more people like Huff are surviving cancers that were once considered a death sentence, like lung, pancreatic and brain cancer. “Being able to identify exactly what makes a cancer tick is having an incredible impact,” says David Thomas, a pioneer of precision oncology at the University of New South Wales in Sydney. But surprisingly, it has received little fanfare outside of the medical community so far.

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Posted in Children, Health & Medicine, Marriage & Family, Science & Technology

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