The actress Christina Applegate, who received a multiple sclerosis diagnosis in 2021, said on Tuesday that she had been unexpectedly plunged back into uncertainty after a doctor told her she didn’t have multiple sclerosis after all.
“This may come as great news, but to me it comes as like I’m back at square one,” Ms. Applegate said on “MeSsy,” a podcast she hosts with the actress Jamie-Lynn Sigler. She broke into tears as she described the doctor’s words: “She came into my room and she said, ‘Congratulations, you don’t have M.S.’”
“Well, I was not happy at all,” she said, explaining that her symptoms did not go away when the diagnosis did. “Everybody else was so happy.”
“You don’t get misdiagnosed and then all of a sudden I’m better,” she added.
The about-face, Ms. Applegate said, doesn’t mean she’s not sick anymore. It means she’s still sick but doesn’t know why — a common experience for people with complex chronic illnesses, and one Ms. Applegate already went through for years before receiving her M.S. diagnosis.
Misdiagnosed: Christina Applegate said she learned she was misdiagnosed with multiple sclerosis five years ago. She tells how she’s “back at square one." https://t.co/kNKf8xbrBd
— NBC4 Washington (@nbcwashington) October 20, 2026
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