(Hopkins Medicine) Could Just 5 weeks of brain training protect against dementia for 20 years?

Adults age 65 and older who completed five to six weeks of cognitive speed training — in this case, speed of processing training, which helps people quickly find visual information on a computer screen and handle increasingly complex tasks in a shorter time period — and who had follow-up sessions about one to three years later were less likely to be diagnosed with dementia, including Alzheimer’s disease, up to two decades later, according to new findings published today in Alzheimer’s & Dementia: Translational Research and Clinical Interventions.

This National Institutes of Health (NIH)-funded study is the first randomized clinical trial, and only study of its kind, to assess 20-year links with dementia, including Alzheimer’s disease, among adults who participated in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study. Investigators enrolled 2,802 adults into this study in 1998–99 to assess long-term benefits of participants randomized to three different types of cognitive training — memory, reasoning and speed of processing — in comparison to a control group who received no training. In the three training groups, participants received up to 10 sessions of 60–75 minutes of cognitive training that took place over five to six weeks. Additionally, half of participants were randomized to receive up to four additional cognitive training sessions, or boosters, which took place 11 and 35 months after the initial training.

In this 20-year follow-up study, investigators found that 105 out of 264 (40%) participants in the speed-training group with boosters were diagnosed with dementia, which was a 25% reduced incidence compared to 239 out of 491 (49%) adults in the control arm. This was the only intervention with a statistically significant, or meaningful, difference compared to the control group.

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A type of cognitive training that tests people's quick recall seems to reduce the risk of dementia, including Alzheimer's disease https://t.co/1ntw4Q2cgE

— New Scientist (@newscientist) February 12, 2026