First, the research is clear that the great majority of current drug-related harm and economic costs arise not from the misuse of illegal drugs but from legal, regulated drugs: tobacco and alcohol. The extent of harm and costs is enormous, and continues year after year.
The epidemic of opioid deaths that has been sweeping across North America had its genesis in the conduct of the legal pharmaceutical drug industry.
Second, we have a history of pan-industry failure to balance revenue interests with the protection of public health. Industries protect their revenue by disregarding existing regulations and opposing the introduction of new evidence-based reforms. They also have a history of breaking the law to maximize revenues.
Third, government has been reluctant to adopt evidence-based regulatory reforms, and the effectiveness of existing regulations is often compromised by permissive enforcement. Rarely-assessed penalties are typically insufficient to discourage recidivism. In sum, drug industry regulation is not simply less than perfect, it is seriously less than adequate, and contributes to the perennial high levels of harm from drug products.