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(SA) Alzheimer’s Drugs Are Finally Tackling the Disease Itself. Here’s How


Alzheimer’s disease has proved to be a tricky target, and researchers and drug developers have been pursuing effective treatments for decades. Debates rage over the disorder’s underlying causes, and various approaches have faced one hurdle after another. But the field has reached a turning point. Over the past four years the U.S. Food and Drug Administration has approved several therapies that address some of the condition’s potential biological roots rather than merely mitigating symptoms—a key scientific milestone. Despite the advances, however, there is still a long list of open questions and so much work to be done.

The brains of people who die with Alzheimer’s show a distinct biology: clumps or “plaques” of amyloid beta proteins in spaces between neurons and tangles of tau proteins that accumulate primarily within the nerve cells. One prevailing theory holds that amyloid builds up early, and tau tangles develop when nerve cell damage is underway but cognitive symptoms are not yet apparent. Over time these pathogenic, or disease-causing, proteins disrupt nerve cell communication. The newest treatments—lecanemab and donanemab—bind to amyloid beta proteins, clear them from the brain and modestly slow cognitive decline.

But the progression from disease-linked proteins to actual dementia is long and inexact, and amyloid and tau proteins accumulate in people with other neurodegenerative disorders, too. With Alzheimer’s there is often a 20- to 30-year lag between the initial detection of amyloid and obvious cognitive decline. According to one study that predicted disease risk based on demographic data, death rates and amyloid status, fewer than one quarter of cognitively healthy 75-year-old women who test positive for amyloid in a spinal fluid analysis or positron-emission tomography (PET) brain scan will develop Alzheimer’s dementia during their lifetime. Such findings suggest that amyloid alone is not driving disease progression and have spurred scientists to investigate other strategies.

Read it all.

Posted in Aging / the Elderly, Health & Medicine, Science & Technology

(Christian Today) Anglican Communion entering a ‘crucial’ period, says Gafcon leader ahead of Nigeria meeting

The Most Reverend Dr Laurent Mbanda, Chairman of the Gafcon Primates Council, has called on all “orthodox” bishops within the Anglican Communion to join a meeting in Abuja, Nigeria in early March next year.

Gafcon is a global alliance of orthodox Anglicans who are opposed to the promotion and acceptance of homosexuality, particularly within the leadership of the church. It was founded in 2008, in part as a response to the consecration of the openly gay Gene Robinson as a bishop in the US Episcopal Church in 2003.

Archbishop Mbanda said that the next six months represent a “crucial” period for the Anglican Communion, and that the Gafcon meeting, to be held from 3 to 6 March, “may be the most important assembly of authentic Anglicans since Gafcon reset the Communion at Jerusalem in 2008”.

He warned, “Revisionists deliberately divide the Communion with schismatic actions that celebrate sin, as they appoint false shepherds to lead their flock away from God’s good word. But Jesus is building his church, and the gates of Hell will not prevail!”

Read it all.

Posted in Church of Rwanda, GAFCON, Global South Churches & Primates

(CT) Jesus Uses Money to Diagnose Our Spiritual Bankruptcy

When students in my Old Testament courses contrast the allegedly messy world of the first testament with the allegedly simple, straightforward teachings of Jesus, I know for sure they haven’t read the New Testament lately. When we read the Gospels, not least Jesus’ parables, we discover him saying all sorts of bizarre, borderline offensive things.

Keith Bodner is here to help relieve our confusion. His new book, Exploring the Financial Parables of Jesus: The Economy of Grace and the Generosity of God, gives a tour of God’s “economy of grace” by focusing on “parables with a financial edge.” Indeed, Bodner suggests these parables provide “an excellent point of entry into the larger biblical story.”

Along the way, as Bodner invites us to learn from the parables, he also offers guidance on immersing ourselves in them as readersThe book thus inspires readers to engage a genre of biblical literature Bodner playfully dubs the “TikTok of the New Testament,” while equipping them with tools to engage it well.

Read it all.

Posted in Anthropology, Christology, Ethics / Moral Theology, Personal Finance & Investing, Stewardship, Theology, Theology: Scripture

(Wired) Will Whole-Genome Sequencing Will Change Pregnancy?

The world of pregnancy is going to radically change, predicts Noor Siddiqui. “I think that the default way people are going to choose to have kids is via IVF and embryo screening,” she said at the WIRED Health summit last week. “There’s just a massive amount of risk that you can take off of the table.”

Siddiqui is the founder and CEO of Orchid, a biotech company that offers whole-genome screening of embryos for IVF. By analyzing the DNA of different embryos before selecting which one to implant, Orchid says, parents can lower the risk their children grow up affected by conditions with a genetic basis. Siddiqui was speaking with George Church—a pioneer in genomics and a professor of genetics at Harvard Medical School—at the summit in Boston, exploring the promise and potential of whole-genome sequencing.

An estimated 4 percent of people worldwide have a disease that’s caused by a single genetic mutation. With embryo screening, “these monogenic diseases can be just completely avoided,” Siddiqui said. On top of this, roughly half the world’s population suffers from a chronic disease with at least some genetic basis. Analyze five embryos ahead of implanting one, Siddiqui said, and “you can now mitigate the genetic component of that risk by these double-digit numbers. You’re talking about in the worst case 30 percent and in the best case up to 80 percent.”

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Posted in Children, Marriage & Family, Science & Technology

A Prayer for the Feast Day of Hildegard of Bingen

O God, by whose grace thy servant Hildegard, enkindled with the fire of thy love, became a burning and shining light in thy Church: Grant that we also may be aflame with the spirit of love and discipline, and may ever walk before thee as children of light; through Jesus Christ our Lord, who with thee, in the unity of the Holy Spirit, liveth and reigneth, one God, now and for ever.

Posted in Church History, Spirituality/Prayer

A Prayer to Begin the day from the Pastor’s Prayerbook

Help us this day, O God, to serve thee devoutly, and the world busily.  May we do our work wisely, give succour secretly, go to our meat appetitely, sit thereat discreetly, arise temperately, please our friend duly, go to our bed merrily, and sleep surely; for the joy of our Lord, Jesus Christ.

–Robert W. Rodenmayer, ed., The Pastor’s Prayerbook: Selected and arranged for various occasions (New York: Oxford University Press, 1960)

Posted in Spirituality/Prayer

From the Morning Bible Readings

When I came to you, brethren, I did not come proclaiming to you the testimony of God in lofty words or wisdom. For I decided to know nothing among you except Jesus Christ and him crucified. And I was with you in weakness and in much fear and trembling; and my speech and my message were not in plausible words of wisdom, but in demonstration of the Spirit and of power, that your faith might not rest in the wisdom of men but in the power of God.

Yet among the mature we do impart wisdom, although it is not a wisdom of this age or of the rulers of this age, who are doomed to pass away. But we impart a secret and hidden wisdom of God, which God decreed before the ages for our glorification. None of the rulers of this age understood this; for if they had, they would not have crucified the Lord of glory. But, as it is written,

“What no eye has seen, nor ear heard,
nor the heart of man conceived,
what God has prepared for those who love him,”

God has revealed to us through the Spirit. For the Spirit searches everything, even the depths of God.

–1 Corinthians 2:1-10

Posted in Theology: Scripture

Sermon section I preached on the Utah assassination on Sunday

“Now let me say a word to all of us about the importance of Christians being Christians. I want to speak to you from my heart and tell you that you matter not just to God, not just to me not just this Parish, but to this country and the most important thing for the country right now is for Christians to be Christians and to be salt and light.

There’s no question that the last week has been unspeakably difficult for our country. We had a man who was speaking publicly at a university in Utah senselessly murdered in cold blood. It caused terror and shock to the students, to the university, to the state of Utah, to the country and indeed to the world.

Whatever else you can say about this terrible event it represents the symptom of a country that is not well. We need Christians to pray for this country but we need more than that. We need Christians to be Christians in the public sphere in this country and behave in the public Square in a manner that conforms with the person and the teachings of Christ.

This means two things specifically for us. First of all, it means speaking against political violence from any point of view as ever being justified in the public square. Christians need to be people who defend free speech, but also who defend the importance of good disagreement in public and who do everything in their power to pray and speak against any political violence.

There is also something philosophical at stake and it matters. One of the very alarming things that’s happened in the last few decades is that a perspective has emerged, which has moved from arguing that words are bad to arguing that words in and of themselves are violence.

We need to be careful here. There is no justification for using free speech to deliberately incite violence from others or ourselves, but this is different.

What is now being argued is that words of a certain type from a certain vantage point are inherently violent and therefore people who use those kind of words and those kind of arguments are able to be responded to with violence in certain circumstances.

Do not fool yourself that this idea that political violence is justified is somehow hiding anymore in the dark subways or smaller parts of our country. What is so deeply disturbing about what this week represents is how many people in public from various viewpoints are more and more justifying political violence as a means of somehow being a solution to our problems Political violence has never been good. It will never be justified. It can never be condoned. It must always be condemned.

This is true for everyone, but especially for us as Christians. Let us renew our commitment to pray for this country and let us renew our commitment to seek the common good, to defend the importance of the public square and to defend the need to behave properly in the public square. And let us all work for the common good of our country.

Several people have argued that this week could be a turning point—let us pray that it is, in all sorts of ways, a turning point for the better, but let us, especially as Christians, respond by making sure that it deepens our resolve to be people of salt and light who speak the truth in love and who declare to all that speaking the truth in love matters. And let us pray that the God who brought his light into the darkness of this world, somehow brings his light out of this very dark week in Utah and in America.”

Posted in * By Kendall, * South Carolina, America/U.S.A., Anthropology, Ethics / Moral Theology, Ministry of the Ordained, Parish Ministry, Preaching / Homiletics, Sermons & Teachings, Theology, Violence

(AM) Professor Irene Tuffrey Wijne–[So-called] Assisted Dying and people with learning disabilities

If doctors find it too difficult to assess ‘unbearable suffering’ they referred the person to an ‘end of life’ clinic. If the second doctor did not agree it was referred to a third doctor. This becomes ‘doctor shopping’.

A committee cannot assess if someone’s suffering is ‘unbearable’.

Doctors have to be able to imagine a person’s suffering. But autistic pain is difficult to assess and so doctors have to take the autistic person’s word for it. The suffering of an autistic person is different from that of a non-autistic person.

In quite a few instances there was no physical illness that was terminal. One person found it too difficult to eat more than three meals a day – required because of their condition.

The Dutch ‘openness’ is good and good that there is scrutiny through the reports being made available online.  There was a change in the culture and unspoken pressure to accept this way of dying.  But there is no 6 month limitation and the law may be being expanded too much. The interpretation of the law expanded while the law itself was unchanged,

Disabled people cannot be excluded from the law on account of their disability because that would be discrimination. The disabled have the same rights as everyone.

Read it all.

Posted in Aging / the Elderly, Anthropology, Death / Burial / Funerals, England / UK, Ethics / Moral Theology, Health & Medicine, Life Ethics, The Netherlands, Theology

Tuesday Food for Thought–Ernst Käsemann on the nature of human beings right now according to the New Testament

“…all through the world [sin] takes possession of us as power and destiny…. There is no such thing as human autonomy. One is never simply oneself but always the projection of an all-encompassing power, the copy and image of whichever lord has commandeered one for service.”

–Ernst Käsemann, “The Theological Relevance of the Word ‘Possession’ in the New Testament, in On Being a Disciple of the Crucified Nazarene (Eerdmans, 2010), 64, cited by yours truly in a recent sermon

Posted in Anthropology, Theology, Theology: Scripture, Uncategorized

(Economist leader) Is British politics broken? Its centre is cracking

When Keir Starmer was elected just over a year ago, Labour ministers warned that their government was Britain’s last chance to see off populism. The political centre has sprung a leak even sooner than they feared. Just one in five voters now supports the government; Sir Keir’s personal ratings as prime minister are dire. On September 5th Angela Rayner, his deputy, resigned over unpaid taxes, prompting a wide cabinet reshuffle.

The extremes, meanwhile, are all fired up. Whereas the Conservative Party is moribund, Nigel Farage, the leader of the hard-right Reform UK, told his party conference that he would be prime minister as soon as 2027. Although Reform has just four MPs, he is not delusional: were an election held tomorrow, Reform would have a coin-toss chance of a majority. Other insurgents sense their moment, too. Zack Polanski, a self-styled “eco-populist”, is the new leader of the once-fusty Green Party, with a pitch to be the Farage of the left. Jeremy Corbyn, whose self-belief is undented by four and a half calamitous years as the Labour Party’s leader, is running a new hard-left outfit.

Britain is not the only democracy where the centre is crumbling. On September 8th France’s centrist government fell over spending cuts, caught in a pincer of the hard left and right. In Germany the established centre parties have steadily lost votes, as the political system has fragmented. The middle is hollowing out in America, too, as voters are polarised between MAGA and a mob of fight-the-oligarchy lefties. The difference is that Sir Keir still has a commanding majority in the House of Commons. He must use it.

Read it all.

Posted in England / UK, Politics in General

A Prayer for the Feast Day of Ninian of Galloway

O God, who by the preaching of thy blessed servant and bishop Ninian didst cause the light of the Gospel to shine in the land of Britain: Grant, we beseech thee, that, having his life and labors in remembrance, we may show forth our thankfulness by following the example of his zeal and patience; through Jesus Christ our Lord, who liveth and reigneth with thee and the Holy Spirit, one God, for ever and ever.

Posted in Church History, Church of Ireland, Spirituality/Prayer

A prayer for the day from Frank Colquhoun

Almighty God, who in Christ Jesus hast fulfilled to the sons of men thy ancient word of promise: Grant us grace to lay hold upon that promise by a living faith, that we may receive thy gift of righteousness, and at the last may enter upon our eternal inheritance; through the merits of the same thy Son, Jesus Christ our Lord.

Posted in Spirituality/Prayer

From the Morning Bible Readings

Hear my cry, O God, listen to my prayer; from the end of the earth I call to thee, when my heart is faint. Lead thou me to the rock that is higher than I; for thou art my refuge, a strong tower against the enemy. Let me dwell in thy tent for ever! Oh to be safe under the shelter of thy wings!

–Psalm 61:1-4

Posted in Theology: Scripture

Prayers for the Anglican Diocese of South Carolina this week

Posted in * Anglican - Episcopal, * South Carolina, Parish Ministry, Spirituality/Prayer

A Prayer for the day from the Church of England

Almighty God,
who in the passion of your blessed Son
made an instrument of painful death
to be for us the means of life and peace:
grant us so to glory in the cross of Christ
that we may gladly suffer for his sake;
who is alive and reigns with you,
in the unity of the Holy Spirit,
one God, now and for ever.
Amen.

Posted in Spirituality/Prayer

From the Morning Scripture Readings

Then Jesus was led up by the Spirit into the wilderness to be tempted by the devil. And he fasted forty days and forty nights, and afterward he was hungry. And the tempter came and said to him, “If you are the Son of God, command these stones to become loaves of bread.” But he answered, “It is written,

‘Man shall not live by bread alone,
but by every word that proceeds from the mouth of God.’”

Then the devil took him to the holy city, and set him on the pinnacle of the temple, and said to him, “If you are the Son of God, throw yourself down; for it is written,

‘He will give his angels charge of you,’

and

‘On their hands they will bear you up,
lest you strike your foot against a stone.’”

Jesus said to him, “Again it is written, ‘You shall not tempt the Lord your God.’” Again, the devil took him to a very high mountain, and showed him all the kingdoms of the world and the glory of them; and he said to him, “All these I will give you, if you will fall down and worship me.” Then Jesus said to him, “Begone, Satan! for it is written,

‘You shall worship the Lord your God
and him only shall you serve.’”

Then the devil left him, and behold, angels came and ministered to him.

–Matthew 4:1-11

Posted in Theology: Scripture

A prayer for the day from the ACNA prayerbook

O God, because without you we are not able to please you, mercifully grant that your Holy Spirit may in all things direct and rule our hearts; through Jesus Christ our Lord, who lives and reigns with you and the Holy Spirit, one God, now and for ever.  Amen.

Posted in Spirituality/Prayer

From the Morning Bible readings

The earth is the Lord’s and the fullness thereof,
the world and those who dwell therein,
for he has founded it upon the seas
and established it upon the rivers.

–Psalm 24:1-2

Posted in Theology: Scripture

A Prayer for the Feast Day of Saint Cyprian of Carthage

Almighty God, who didst give to thy servant Cyprian boldness to confess the Name of our Savior Jesus Christ before the rulers of this world, and courage to die for this faith: Grant that we may always be ready to give a reason for the hope that is in us, and to suffer gladly for the sake of the same our Lord Jesus Christ; who liveth and reigneth with thee and the Holy Spirit, one God, for ever and ever.

Posted in Africa, Church History, Spirituality/Prayer

A Prayer to Begin the day from Thomas Bradwardine (c 1300-1349)

My God, I love Thee Thyself above all else, and Thee I desire as my last end. Always and in all things, with my whole heart and strength, and with unceasing labour, I seek Thee. If Thou give not Thyself to me, Thou givest nothing: if I find not Thee, I find nothing. Grant to me, therefore, most loving God, that I may ever love Thee for Thyself above all things and seek Thee in all things in this life present, so that at last I may find Thee and keep Thee for ever in the world to come.

–Frederick B. Macnutt, The prayer manual for private devotions or public use on divers occasions: Compiled from all sources ancient, medieval, and modern (A.R. Mowbray, 1951)

Posted in Uncategorized

From the Morning Bible Readings

Then Jesus came from Galilee to the Jordan to John, to be baptized by him. John would have prevented him, saying, “I need to be baptized by you, and do you come to me?” But Jesus answered him, “Let it be so now; for thus it is fitting for us to fulfil all righteousness.” Then he consented. And when Jesus was baptized, he went up immediately from the water, and behold, the heavens were opened and he saw the Spirit of God descending like a dove, and alighting on him; and lo, a voice from heaven, saying, “This is my beloved Son, with whom I am well pleased.”

–Matthew 3:13-17

Posted in Theology: Scripture

(Church Times) Lords Spiritual gather behind opposition to assisted-dying Bill

Bishops decried the proposed legalisation of assisted dying on Friday, as the Terminally Ill Adults (End of Life) Bill came to the House of Lords for the first of two days of debate.

“If passed, this Bill will signal that we are a society that believes that some lives are not worth living,” the Bishop of London, the Rt Revd Sarah Mullally, said. It would become, she said, the “state-endorsed position”.

Bishop Mullally, a former Chief Nursing Officer, questioned whether Parliament had properly listened to the advice of medical experts, including professional bodies which have expressed concerns about the legislation.

The Bill also failed in its “central claim” to give people choice about the manner of their death, she said. “A meaningful choice would see the measures in this Bill set alongside easily available, fully-funded, palliative and social-care services. Without a choice offered, this choice is an illusion.”

Read it all.

Posted in * Culture-Watch, Aging / the Elderly, Anthropology, Church of England (CoE), CoE Bishops, Death / Burial / Funerals, England / UK, Ethics / Moral Theology, Health & Medicine, Law & Legal Issues, Life Ethics, Secularism, Theology

(WSJ) U.S. Population Growth Will Slow Even More, CBO Says–Deaths now forecast to exceed births in 2031

U.S. population growth will slow to a crawl over the next few decades as fertility rates decline and net immigration shrinks because of stricter enforcement, the Congressional Budget Office said Wednesday.

Deaths are now projected to exceed births in 2031. Just eight months ago, CBO had projected that threshold wouldn’t be crossed until 2033.  

By 2055, the U.S. population will be about 367 million, up from 350 million today. In January, CBO had projected a 2055 population of 372 million. From 1975 through 2024, U.S. population growth averaged 0.9% annually. By the early 2050s, according to the latest projections, population growth will effectively be zero. 

Read it all.

Posted in * Culture-Watch, America/U.S.A., Children, Marriage & Family

(Morgan Stanley) The number of robots that resemble and act like humans is likely to reach nearly 1 billion by 2050

By 2050, about 90% of humanoids, or about 930 million units, will likely be used for repetitive, simple, and structured work—primarily industrial and commercial purposes. China is likely to have the highest number of humanoid robots in use by 2050, at 302.3 million, trailed by the U.S. at  77.7 million (up from the previous forecast of 63 million).

“The forecast for household usage is much more conservative, with only 80 million humanoids in homes by 2050,” Jonas says. “We are not going to see a robot in every home overnight.”

Creating a general-purpose humanoid that is capable of doing a vast array of useful tasks at home will require technological progress in both hardware and AI models, which should take about another decade. To get those humanoids into homes, prices need to decline significantly, in parallel with regulatory and societal acceptance of this use of humanoids.

“Once we get to that stage, humanoid volume and penetration should pick up quickly,” Jonas says.

Read it all.

Posted in Science & Technology

The Lamb of God, a sermon by Bishop John Henry Hobart for his Feast Day

The striking and appropriate terms in which the prophet Isaiah depicts the character and offices of the Messiah, have procured for him, by way of eminence, the title of the Evangelical Prophet. He exhibits a glowing but faithful picture of the character of Christ, and all the humiliating and all the triumphant events of his life. In the chapter which contains my text, the prophet has dipped his pencil in the softest colours, and draws a portrait of the Saviour, which, while it conveys to us the most exalted ideas of his character, is calculated to awaken our tenderest and liveliest sympathy.

Posted in Church History, Ministry of the Ordained, Preaching / Homiletics

A Prayer for the Feast Day of John Henry Hobart

Revive thy Church, Lord God of hosts, whensoever it doth fall into complacency and sloth, by raising up devoted leaders, like thy servant John Henry Hobart whom we remember this day; and grant that their faith and vigor of mind may awaken thy people to thy message and their mission; through Jesus Christ our Lord, who liveth and reigneth with thee and the Holy Spirit, one God, for ever and ever.

Posted in Church History, Spirituality/Prayer

A prayer for the day from Euchologium Anglicanum

O Gracious God, whose blessed Son set forth thy love towards mankind, in his miracles of healing and mercy, making both the deaf to hear and the dumb to speak: Grant that our ears may be opened to thy Word, and our tongues loosed to proclaim it to others, and to further the spreading of thy gospel among all nations; through the same Jesus Christ our Lord.

Posted in Spirituality/Prayer

From the Morning Bible Readings

In those days came John the Baptist, preaching in the wilderness of Judea, “Repent, for the kingdom of heaven is at hand.” For this is he who was spoken of by the prophet Isaiah when he said, “The voice of one crying in the wilderness: Prepare the way of the Lord, make his paths straight.” Now John wore a garment of camel’s hair, and a leather girdle around his waist; and his food was locusts and wild honey. Then went out to him Jerusalem and all Judea and all the region about the Jordan, and they were baptized by him in the river Jordan, confessing their sins. But when he saw many of the Pharisees and Sad’ducees coming for baptism, he said to them, “You brood of vipers! Who warned you to flee from the wrath to come? Bear fruit that befits repentance, and do not presume to say to yourselves, ‘We have Abraham as our father’; for I tell you, God is able from these stones to raise up children to Abraham. Even now the axe is laid to the root of the trees; every tree therefore that does not bear good fruit is cut down and thrown into the fire. “I baptize you with water for repentance, but he who is coming after me is mightier than I, whose sandals I am not worthy to carry; he will baptize you with the Holy Spirit and with fire. His winnowing fork is in his hand, and he will clear his threshing floor and gather his wheat into the granary, but the chaff he will burn with unquenchable fire.”

–Matthew 3:1-12

Posted in Theology: Scripture

May we Never Forget Twenty-Four Years Ago Today–A Naval Academy “Anchormen” Tribute to 9/11

Posted in History, Military / Armed Forces, Music, Terrorism