The Bible begins with the words “In the beginning God created the heavens and the earth”. One chapter later, we’re told that when God created the world he was “at work”. That the very first thing we learn about God is that he is a worker is very significant.

The nations around Israel believed that humans were created because the gods didn’t want to work – work was beneath them. But the Scriptures show us a God who works. Work is not an evil necessity but something associated with God’s character and so, when he creates humans and tells them to go and work in his garden, this is not a jail sentence but a privilege.

Genesis 2 also tells us that God rested. He worked and he rested, and in so doing established a pattern for us. Humans aren’t made for work alone but for work and rest. And as Hebrews tells us, rest is ultimately about our eternal relationship with God. We are made for the heavenly rest where we enjoy the presence of the living God and life full of joy and relationship in a renewed heavens and earth.

Against this backdrop we read that God created us. And there are two really important truths here. First, we are created in the image of God. And second, as those created in God’s image we are created specifically for work.

When God made men and women – to fill the earth and to rule over it – he gave us the privilege of working as his agents in his creation. It’s easy for us to miss the significance of this. Work is very, very good. Work is not the thing that you do to get to the good bits. There is something good about work, even when it’s very “worky”! Even when it’s tiring and difficult.

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Joseph the Carpenter by Georges de La Tour, circa 1642.#YearofStJoseph pic.twitter.com/bzbZRYUnuk

— Brant Law (@Mr_BLaw) July 29, 2021

More than 190 countries have reached a landmark deal for protecting the biodiversity of the world’s oceans, agreeing for the first time on a common framework for establishing new protected areas in international waters.

The treaty, whose text was finalized Saturday night by diplomats at the U.N. headquarters after years of stalled talks, will help safeguard the high seas, which lie beyond national boundaries and make up two-thirds of Earth’s ocean surface. Member states have been trying to agree on the long-awaited treaty for almost 20 years.

Environmental advocacy groups heralded the finalized text — which still needs to be ratified by the United Nations — as a new chapter for Earth’s high seas. Just 1.2 percent of them are currently environmentally protected, exposing the vast array of marine species that teem beneath the surface — from tiny plankton to giant whales — to threats such as pollution, overfishing, shipping and deep-sea mining.

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More than 190 countries have reached a landmark deal for protecting the biodiversity of the world’s oceans, agreeing for the first time on a common framework for establishing new protected areas in international waters.https://t.co/vbfbMP1329

— The Washington Post (@washingtonpost) March 5, 2023

In the contest of the century—the U.S. rivalry with China—the deciding factor will be innovation power. Technological advances in the next five to ten years will determine which country gains the upper hand in this world-shaping competition. The challenge for the United States, however, is that government officials are incentivized to avoid risk and focus on the short term, leaving the country to chronically underinvest in the technologies of the future.

If necessity is the mother of invention, war is the midwife of innovation. Speaking to Ukrainians on a visit to Kyiv in the fall of 2022, I heard from many that the first months of the war were the most productive of their lives. The United States’ last truly global war—World War II—led to the widespread adoption of penicillin, a revolution in nuclear technology, and a breakthrough in computer science. Now, the United States must innovate in peacetime, faster than ever before. By failing to do so, it is eroding its ability to deter—and, if necessary, to fight and win—the next war.

The alternative could be disastrous. Hypersonic missiles could leave the United States defenseless, and cyberattacks could cripple the country’s electric grid. Perhaps even more important, the warfare of the future will target individuals in completely new ways: authoritarian states such as China and Russia may be able to collect individual data on Americans’ shopping habits, location, and even DNA profiles, allowing for tailor-made disinformation campaigns and even targeted biological attacks and assassinations. To avert these horrors, the United States needs to make sure it remains ahead of its technological competitors.

The principles that have defined life in the United States—freedom, capitalism, individual effort—were the right ones for the past and remain so for the future. These basic values lie at the foundation of an innovation ecosystem that is still the envy of the world. They have enabled breakthroughs that have transformed everyday life around the world. The United States started the innovation race in pole position, but it cannot rest assured it will remain there. Silicon Valley’s old mantra holds true not just in industry but also in geopolitics: innovate or die.

Read it all (registration).

Eric Schmidt: Why Technology Will Define the Future of Geopolitics https://t.co/LP2imSEoSu

— Albert Royo (@AlbertRoyo5) February 28, 2023

Chinese researchers lead their American counterparts in the study of dozens of critical technologies, according to a new report that proposes Beijing is dominant in some scientific pursuits and positioned to develop key future breakthroughs.

The report, published Thursday by the Australian Strategic Policy Institute, puts Chinese researchers ahead of Americans in 37 of 44 technologies examined, across the sectors of defense, space, robotics, energy, environment, biotechnology, artificial intelligence, advanced materials and quantum technology.

“In the long term, China’s leading research position means that it has set itself up to excel not just in current technological development in almost all sectors, but in future technologies that don’t yet exist,” ASPI concludes. No other nation is close to China and the U.S. in the research race, according to the Canberra-based think tank, which is primarily funded by Australia’s government. The report put India and the U.K. distantly behind them in most sectors, followed by South Korea and Germany.

The report says China’s research interest and performance in military and space sectors are particularly notable….

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Beijing is globally dominant in some scientific pursuits and positioned to develop key future breakthroughs, the Australian Strategic Policy Institute says https://t.co/3SjLk37lu2

— The Wall Street Journal (@WSJ) March 2, 2023

Xi Jinping, China’s most powerful leader since Mao Zedong, is preparing to use the upcoming rubber-stamp parliamentary session to launch a “forceful” overhaul of the government by appointing his most trusted acolytes to oversee the financial, technology and other sectors.

The annual National People’s Congress, which kicks off on Sunday, will replace Premier Li Keqiang, the head of government, and his team of technocrats that has been credited with steering the economy through the turmoil of the past five years. Important portfolios such as the financial sector may also be restructured.

Xi pledged at a meeting on Tuesday that the party was planning “far-reaching” changes which, aside from financial sector reform, would include exerting closer control over the technology and science sectors and — perhaps most ominously for business — increased party involvement in “non-public enterprises”.

The changes come at a sensitive moment for China’s economy, which was hamstrung by Xi’s draconian zero-Covid strategy last year and regulatory crackdowns on the tech and property sectors that have damaged business sentiment. Gross domestic product in 2022 grew just 3 per cent, well below the official target of 5.5 per cent.

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Xi Jinping, China’s most powerful leader since Mao Zedong, is preparing to launch a 'forceful' overhaul of the government by appointing his most trusted acolytes to oversee the financial, technology and other sectors https://t.co/mQWZnHwX8Y

— FT China (@ftchina) March 2, 2023

Bush never stipulates that the rest of the world must “become like America” in so many words. How could he? The whole point of his rhetoric was to assure himself that he was at the helm of the gigantic killing machine that is the United States military not merely to protect and promote American interests, but in order to bring the blessings of liberty to every corner of the earth. The final paragraph of Bush’s introduction reveals the self-deception:

Freedom is the non-negotiable demand of human dignity; the birthright of every person—in every civilization. Throughout history, freedom has been threatened by war and terror; it has been challenged by the clashing wills of powerful states and evil designs of tyrants; and it has been tested by widespread poverty and disease. Today, humanity holds in its hands the opportunity to further freedom’s ­triumph over all these foes. The United States welcomes our responsibility to lead in this great mission.

One is hard pressed to imagine a more utopian vision—freedom’s triumph over all its foes! But Bush was president of the United States, not of the world. Moreover, this document and its urgency stemmed from the terrorist attacks of September 11, 2001. There can be no doubt that Bush was concerned for the weal and woe of Americans.

We can substitute America or American interests for the key word “freedom” in this final paragraph without altering the strategic implications. Indeed, if we make these substitutions, Bush’s words become more faithful to events. Here is my rendering in that spirit:

Being American is the non-negotiable demand of human dignity; the birthright of every person—in every civilization. Throughout history, American interests have been threatened by war and terror; they have been challenged by clashing wills of powerful states and evil designs of tyrants. . . . Today, humanity holds in its hands the opportunity to further America’s triumph over all these foes. The United States welcomes our responsibility to lead in this great mission.

To speak about America in this way seems rather grandiose. But in truth, both versions, Bush’s actual words and my rendition, border on the delusional. This is perhaps to be expected. Baby Boomers were intoxicated by the fusion of hard responsibilities with the most exalted moral idealism. An intoxicated person has blurred vision and a tenuous grasp on reality, and he often makes bad judgments.

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Cursed by the Boomers by R. R. Reno | Articles | First Things https://t.co/qLylAU4XXl

— Allen Mendenhall (@allenmendenhall) February 14, 2023

China is in the midst of a quiet but stunning nationwide collapse of birthrates. This is the deeper, still largely overlooked, significance of the country’s 2022 population decline, announced by Chinese authorities last month.

As recently as 2019, demographers at the U.S. Census Bureau and the United Nations were not expecting China’s population to start dropping until the early 2030s. But they did not anticipate today’s wholesale plunge in childbearing.

Considerable attention has been devoted to likely consequences of China’s coming depopulation: economic, political, strategic. But the causes of last year’s population drop deserve much closer examination.

China’s nosedive in childbearing is a silent alarm. It signals deep disaffection with the bleak future the regime is engineering for its subjects. In this land without democracy, the birth collapse can be read as a landslide vote of no confidence in President Xi Jinping’s rule.

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"China’s nosedive in childbearing is a silent alarm. It signals deep disaffection with the bleak future the regime is engineering (…). In this land without democracy, the birth collapse can be read as a landslide vote of no confidence in (Xi’s) rule."https://t.co/Yx3m7HXGeA

— Chris Alexander 🌻 (@calxandr) March 1, 2023

It’s been a widely accepted trend in financial circles for nearly two decades. But suddenly, Republicans have launched an assault on a philosophy that says that companies should be concerned with not just profits but also how their businesses affect the environment and society.

More than $18 trillion is held in investment funds that follow the investing principle known as E.S.G. — shorthand for prioritizing environmental, social and governance factors — a strategy that has been adopted by major corporations around the globe.

Now, Republicans around the country say Wall Street has taken a sharp left turn, attacking what they term “woke capitalism” and dragging businesses, their onetime allies, into the culture wars.

The rancor escalated on Tuesday as Republicans in Congress used their new majority in the House to vote by a margin of 216 to 204 to repeal a Department of Labor rule that allows retirement funds to consider climate change and other factors when choosing companies in which to invest. In the Senate, Republicans are lining up behind a similar effort and have been joined by Senator Joe Manchin III, Democrat of West Virginia.

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(NYT front page) The Cultural and Partisan Divide
Of Socially Conscious #Investing https://t.co/uLO6W0hcKW #economy #stockmarket #ESG #corporations #ecology #culture #21stc

— Kendall Harmon (@KendallHarmon6) March 1, 2023

The promise and perils of America’s counterterrorism campaign were on full display at a remote training base in central Somalia.

It was graduation day for 346 recruits who would join an elite Somali commando unit trained by the State Department, advised by U.S. Special Operations forces, and backed by American air power.

Since last August, the unit, called Danab, has spearheaded a string of Somali army victories against Al Shabab, an Islamist terrorist group that is considered the deadliest of Al Qaeda’s global branches.

“We’re more dedicated than ever,” said Second Lt. Shukri Yusuf Ali, 24, who joined the unit two years ago as one of its few female members and was recently selected to attend the U.S. Army infantry training course at Fort Benning, Ga.

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Nearly two decades after the rise of Al Shabab, Somalia is the most active front in the “forever wars” that the United States has been waging against Islamist extremists since the Sept. 11, 2001, terrorist attacks https://t.co/MImvQabjRM

— Eric Schmitt (@EricSchmittNYT) February 27, 2023

Thirty years ago today, terrorists left a bomb weighing more than a half-ton in a rented van parked beneath the World Trade Center, a workplace for tens of thousands. Its smoldering fuse took about 12 minutes to close the gap between the everyday and the horrific.

The lunchtime blast left a crater several stories deep, sent acrid smoke up the center’s north tower and killed six people. More than 1,000 others were injured that day, including a dark-haired trader just yards from the underground detonation.

Eight years later, that same man, Tim Lang, fled Lower Manhattan as terrorists struck the World Trade Center again, this time with jetliners. He saw the first of its two towers buckle and fall in an attack that killed nearly 3,000 people, including those dear to him.

Mr. Lang is 69 now, with shock-white hair and photos of grandchildren stored in his smartphone. He describes himself as an unremarkable man. Yet he is also an everyman through-line between two remarkable events: the attacks of Sept. 11, 2001, which upended world politics, and the bombing of Feb. 26, 1993, which is less indelibly burned into collective memory but stands as ominous prelude.

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Thirty years ago on Sunday, Tim Lang was injured in the first attack on the World Trade Center — an ominous but often overlooked prelude to 9/11.

"Just about everybody forgets about it," he said. But he does not. https://t.co/dGR8lVXEyr

— The New York Times (@nytimes) February 26, 2023

Vote counting is under way in Nigeria’s tightest presidential election since military rule ended in 1999.

Voting was marred by long delays as polling stations failed to open on time in some areas because of logistical problems and security incidents.

Turnout appeared to be high, with many young, first-time voters arriving before dawn to cast their ballots.

The elections are the biggest democratic exercise in Africa, with 87 million people eligible to vote.

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Andy Vermaut shares:Nigeria election 2023: Votes are counted but final results may take days: The elections are the biggest democratic exercise in Africa, with 87 million people eligible to vote. https://t.co/qQSps3iuLV Thank you pic.twitter.com/LGYkf4uUFT

— Andy Vermaut (@AndyVermaut) February 25, 2023

The posters lining the roads of Lagos show the face of a smiling, bespectacled 70-year-old above a slogan promising renewed hope. Vote for Bola Ahmed Tinubu, pedestrians and drivers negotiating the chaos of the Nigerian commercial capital are told. Vote for peace, justice, unity.

On Saturday, the 6 million inhabitants of Lagos who have collected their voting cards will have to decide whether Tinubu and his ruling All Progressives Congress might fulfil any of these promises. So too will another estimated 81 million voters among the 220 million inhabitants of Africa’s most populous country. Their collective decision will determine the result of Nigeria’s seventh presidential elections since the end of military rule in 1999.

Few doubt the importance of the poll. Analysts speak of a crucial turning point after several years of worsening insecurity and acute economic troubles. Many see a credible poll and progress in tackling the country’s multiple problems as key to stability across a swath of Africa.

“It’s a really very important election and one that will be watched very keenly by people outside Nigeria,” said Murithi Mutiga, the International Crisis Group’s programme director for Africa.

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‘Godfather of Lagos’ is the man to beat in pivotal Nigerian election https://t.co/EU5Xjghcv4

— Guardian news (@guardiannews) February 24, 2023

When Russia invaded Ukraine a year ago, it shocked the world.

Although, in hindsight, it probably shouldn’t have — after all, Russia had amassed at least 100,000 troops along its border with Ukraine in the months leading up to the invasion, insisting all the time that it had no plans to invade.

Moscow had also been rebuffed by the West after it presented NATO with a list of demands asking for the military alliance to essentially roll back its activity in Eastern Europe, and to guarantee that Ukraine would never become a member of NATO.

Needless to say, the Western military alliance refused to accede to Russia’s demands and a few months later, on Feb. 24, 2022, Russian troops invaded Ukraine from the north, east and south of the country. It targeted the capital Kyiv, Kharkiv in the northeast, Donbas in the east, and the southeast of the country, along a swathe of territory reaching across to Crimea — a peninsula Russia had annexed back in 2014.

While Russian forces were able to seize a portion of Ukraine in the east and south, aided by the conduit offered by Russian-occupied Crimea, the overly-ambitious scale and breadth of the invasion quickly came back to haunt Moscow. In April, it was forced to withdraw its forces from the Kyiv area, a retreat seen as a humiliating defeat for Russia.

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After a year of death and destruction, Ukraine braces itself for a major escalation in the war https://t.co/vPM1vf7XNJ

— CNBC (@CNBC) February 24, 2023

Faye Johnson-Smith thought it was too good to be true when her boss said she could have every Wednesday off without a cut in salary.

Her firm was taking part in a six-month trial, testing the costs and benefits of a four-day week on full pay.

Like most of the workers involved, Faye was much happier working shorter hours.

But at the end of the trial almost all the 61 employers, which included a brewery and a fish and chip shop, were also keen to keep the new work pattern.

The scheme, organised by 4 Day Week Global, took place between June and December 2022, and involved organisations across the UK, including some non-profit organisations, as well as private firms in recruitment, software, and manufacturing.

A report assessing its impact has found it had “extensive benefits” particularly for employees’ well-being.

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Big day for the #4DayWeek as we reveal that almost almost every company that took part in the UK four-day week pilot has decided to continue with it at the end of the trial.

Surely the time has now come to begin rolling it out across the country.https://t.co/nKWaPyoQOF

— Joe Ryle (@JoeRRyle) February 21, 2023

Observe good faith and justice towards all nations; cultivate peace and harmony with all. Religion and morality enjoin this conduct; and can it be, that good policy does not equally enjoin it – It will be worthy of a free, enlightened, and at no distant period, a great nation, to give to mankind the magnanimous and too novel example of a people always guided by an exalted justice and benevolence. Who can doubt that, in the course of time and things, the fruits of such a plan would richly repay any temporary advantages which might be lost by a steady adherence to it ? Can it be that Providence has not connected the permanent felicity of a nation with its virtue ? The experiment, at least, is recommended by every sentiment which ennobles human nature. Alas! is it rendered impossible by its vices?

In the execution of such a plan, nothing is more essential than that permanent, inveterate antipathies against particular nations, and passionate attachments for others, should be excluded; and that, in place of them, just and amicable feelings towards all should be cultivated. The nation which indulges towards another a habitual hatred or a habitual fondness is in some degree a slave. It is a slave to its animosity or to its affection, either of which is sufficient to lead it astray from its duty and its interest. Antipathy in one nation against another disposes each more readily to offer insult and injury, to lay hold of slight causes of umbrage, and to be haughty and intractable, when accidental or trifling occasions of dispute occur. Hence, frequent collisions, obstinate, envenomed, and bloody contests. The nation, prompted by ill-will and resentment, sometimes impels to war the government, contrary to the best calculations of policy. The government sometimes participates in the national propensity, and adopts through passion what reason would reject; at other times it makes the animosity of the nation subservient to projects of hostility instigated by pride, ambition, and other sinister and pernicious motives. The peace often, sometimes perhaps the liberty, of nations, has been the victim.

So likewise, a passionate attachment of one nation for another produces a variety of evils. Sympathy for the favorite nation, facilitating the illusion of an imaginary common interest in cases where no real common interest exists, and infusing into one the enmities of the other, betrays the former into a participation in the quarrels and wars of the latter without adequate inducement or justification. It leads also to concessions to the favorite nation of privileges denied to others which is apt doubly to injure the nation making the concessions; by unnecessarily parting with what ought to have been retained, and by exciting jealousy, ill-will, and a disposition to retaliate, in the parties from whom equal privileges are withheld. And it gives to ambitious, corrupted, or deluded citizens (who devote themselves to the favorite nation), facility to betray or sacrifice the interests of their own country, without odium, sometimes even with popularity; gilding, with the appearances of a virtuous sense of obligation, a commendable deference for public opinion, or a laudable zeal for public good, the base or foolish compliances of ambition, corruption, or infatuation.

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#OnThisDay in 1789, George Washington was unanimously elected president of the United States. With 69 electoral votes, Washington won the support of each participating elector. Learn more: https://t.co/lQQfy3UZJe pic.twitter.com/zg12ES5fiM

— Mount Vernon (@MountVernon) February 4, 2023

I now make it my earnest prayer, that God would have you, and the State over which you preside, in his holy protection; that he would incline the hearts of the citizens to cultivate a spirit of subordination and obedience to government; to entertain a brotherly affection and love for one another, for their fellow citizens of the United States at large, and particularly for their brethren who have served in the field; and finally, that he would most graciously be pleased to dispose us all to do justice, to love mercy, and to demean ourselves with that charity, humility, and pacific temper of mind, which were the characteristics of the Divine Author of our blessed religion, and without an humble imitation of whose example in these things, we can never hope to be a happy nation.

I have the honor to be, with much esteem and respect, Sir, your Excellency’s most obedient and most humble servant.

–George Washington
Head-Quarters, Newburg,
8 June, 1783.

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What started as—and legally remains—a celebration of George Washington has transformed into something more https://t.co/GQwGp7hoqB

— National Geographic (@NatGeo) February 20, 2023

Every February, Americans take a day off of work to celebrate the presidents — the chief executives whose ideas, policies and foibles have helped to shape our history. So it’s only fitting that you take a moment to test your knowledge about these 44 prominent Americans with a 20-question quiz from “Presidential,” the Washington Post podcast that explores the presidents’ lives and legacies….

Who was the only president to be elected to more than two terms in office?

Theodore Roosevelt

Franklin D. Roosevelt

John Adams

John Quincy Adams….

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Fellow-Citizens of the Senate and House of Representatives:

I embrace with great satisfaction the opportunity which now presents itself of congratulating you on the present favorable prospects of our public affairs. The recent accession of the important state of North Carolina to the Constitution of the United States (of which official information has been received), the rising credit and respectability of our country, the general and increasing good will toward the government of the Union, and the concord, peace, and plenty with which we are blessed are circumstances auspicious in an eminent degree to our national prosperity.

In resuming your consultations for the general good you can not but derive encouragement from the reflection that the measures of the last session have been as satisfactory to your constituents as the novelty and difficulty of the work allowed you to hope. Still further to realize their expectations and to secure the blessings which a gracious Providence has placed within our reach will in the course of the present important session call for the cool and deliberate exertion of your patriotism, firmness, and wisdom.

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National Engineers Week is always the week in February and encompasses George Washington's birthday, February 22. #EWeek2017 #ScienceMarch pic.twitter.com/Id5NGci4NI

— March For Science (@MarchForScience) February 20, 2017

By the article establishing the executive department it is made the duty of the President “to recommend to your consideration such measures as he shall judge necessary and expedient.” The circumstances under which I now meet you will acquit me from entering into that subject further than to refer to the great constitutional charter under which you are assembled, and which, in defining your powers, designates the objects to which your attention is to be given. It will be more consistent with those circumstances, and far more congenial with the feelings which actuate me, to substitute, in place of a recommendation of particular measures, the tribute that is due to the talents, the rectitude, and the patriotism which adorn the characters selected to devise and adopt them. In these honorable qualifications I behold the surest pledges that as on one side no local prejudices or attachments, no separate views nor party animosities, will misdirect the comprehensive and equal eye which ought to watch over this great assemblage of communities and interests, so, on another, that the foundation of our national policy will be laid in the pure and immutable principles of private morality, and the preeminence of free government be exemplified by all the attributes which can win the affections of its citizens and command the respect of the world. I dwell on this prospect with every satisfaction which an ardent love for my country can inspire, since there is no truth more thoroughly established than that there exists in the economy and course of nature an indissoluble union between virtue and happiness; between duty and advantage; between the genuine maxims of an honest and magnanimous policy and the solid rewards of public prosperity and felicity; since we ought to be no less persuaded that the propitious smiles of Heaven can never be expected on a nation that disregards the eternal rules of order and right which Heaven itself has ordained; and since the preservation of the sacred fire of liberty and the destiny of the republican model of government are justly considered, perhaps, as deeply, as finally, staked on the experiment entrusted to the hands of the American people.

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Oh that New York Times opinion page claiming Americans could never agree on a “national figurehead”… not like we ever called someone “the Father of Our Country” for nearly two and a half centuries. pic.twitter.com/pO68XWusGp

— Craig Bruce Smith (@craigbrucesmith) February 20, 2023

Washington’s Birthday was celebrated on February 22nd until well into the 20th Century. However, in 1968 Congress passed the Monday Holiday Law to “provide uniform annual observances of certain legal public holidays on Mondays.” By creating more 3-day weekends, Congress hoped to “bring substantial benefits to both the spiritual and economic life of the Nation.”

One of the provisions of this act changed the observance of Washington’s Birthday from February 22nd to the third Monday in February. Ironically, this guaranteed that the holiday would never be celebrated on Washington’s actual birthday, as the third Monday in February cannot fall any later than February 21.

Contrary to popular belief, neither Congress nor the President has ever stipulated that the name of the holiday observed as Washington’s Birthday be changed to “President’s Day.”

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Happy #WashingtonsBirthday everyone! pic.twitter.com/g3QywmknLB

— Jim Moore (@MoreCoffeeJim) February 20, 2023

At 82 years old, with an aggressive form of blood cancer that six courses of chemotherapy had failed to eliminate, “Paul” appeared to be out of options. With each long and unpleasant round of treatment, his doctors had been working their way down a list of common cancer drugs, hoping to hit on something that would prove effective—and crossing them off one by one. The usual cancer killers were not doing their job.

With nothing to lose, Paul’s doctors enrolled him in a trial set up by the Medical University of Vienna in Austria, where he lives. The university was testing a new matchmaking technology developed by a UK-based company called Exscientia that pairs individual patients with the precise drugs they need, taking into account the subtle biological differences between people.

The researchers took a small sample of tissue from Paul (his real name is not known because his identity was obscured in the trial). They divided the sample, which included both normal cells and cancer cells, into more than a hundred pieces and exposed them to various cocktails of drugs. Then, using robotic automation and computer vision (machine-learning models trained to identify small changes in cells), they watched to see what would happen.

In effect, the researchers were doing what the doctors had done: trying different drugs to see what worked. But instead of putting a patient through multiple months-long courses of chemotherapy, they were testing dozens of treatments all at the same time.

The approach allowed the team to carry out an exhaustive search for the right drug. Some of the medicines didn’t kill Paul’s cancer cells. Others harmed his healthy cells. Paul was too frail to take the drug that came out on top. So he was given the runner-up in the matchmaking process: a cancer drug marketed by the pharma giant Johnson & Johnson that Paul’s doctors had not tried because previous trials had suggested it was not effective at treating his type of cancer.

It worked. Two years on, Paul was in complete remission—his cancer was gone.

Read it all.

On average, it takes more than 10 years and billions of dollars to develop a new drug.

Incorporating AI into the drug development pipeline could help create cheaper pharmaceuticals faster. https://t.co/xYVZFyA5fY

— MIT Technology Review (@techreview) February 15, 2023

A better way to think about the moral import of gambling, and by extension the ubiquity of online sports betting, is to consider what it reveals about the gambler. The Hebrew and Christian scriptures warn many times against the excessive desire for wealth. It is remarkable, for example, that the last of the 10 commandments forbids the inward, private act of coveting: that is, the desire for what rightfully belongs to someone else. Jesus asserted—similarly referring to an unseeable sin—that a man cannot serve both God and mammon. The apostle Paul called the love of money “the root of all kinds of evil.”

Most forms of gambling, it’s fair to say, manifest a desire for money so inordinate that one is willing to take stupid risks to get more of it. Heavily investing in a stock you haven’t researched, putting your savings in a Ponzi scheme, betting on the Chiefs or the Eagles with money you can’t afford to lose—these are follies of the human heart. Or, to use a plainer word, sins.

Of course, the Bible doesn’t forbid risky investments. Jesus himself encourages a certain kind of them. “The kingdom of heaven is like unto a merchant man, seeking goodly pearls: who, when he had found one pearl of great price, went and sold all that he had, and bought it.”

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Sports betting is no longer taboo. Even the Manning boys say it’s OK. But is it wrong? asks Barton Swaim https://t.co/QHnmzXzURL

— Wall Street Journal Opinion (@WSJopinion) February 10, 2023

President Biden scored an early political point this month in his fight with congressional Republicans over taxes, spending and raising the federal debt limit: He forced Republican leaders to profess, repeatedly, that they will not seek cuts to Social Security and Medicare.

In the process, Mr. Biden has effectively steered a debate about fiscal responsibility away from two cherished safety-net programs for seniors, just as those plans are poised for a decade of rapid spending growth.

New forecasts from the nonpartisan Congressional Budget Office, released on Wednesday, showed Medicare and Social Security spending growth rapidly outpacing the growth in federal tax revenues over the next 10 years. That is the product of a wave of baby boomers reaching retirement age and beginning to tap the programs, which provide guaranteed income and health insurance from the time benefits are claimed until death.

Those retirees are an electoral force. In refusing to touch so-called entitlement programs, Mr. Biden was appealing to seniors, along with generations of future retirees, when he used his State of the Union address and subsequent speeches this month to amplify attacks on Republican plans to reduce future spending on Social Security and Medicare or potentially sunset the programs entirely.

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A healthy country would tackle this program head on and make the necessary adjustments and compromises to do so 4/4 https://t.co/bjLzztGF23 #socialsecurity #medicare #unfundedliabilities #usa #Stewardship all we are doing now is making things worse for those who come after us

— Kendall Harmon (@KendallHarmon6) February 16, 2023

Workers of the world are more exhausted than ever.

More than 40% of people with desk jobs feel burned out at work, a pandemic-era high, according to a survey released Wednesday by Future Forum, a research consortium backed by Salesforce Inc.’s Slack Technologies. The pain is particularly acute outside the US, where the burnout rate has been rising enough to offset slight improvements seen by American workers.

Economic uncertainty, fear of job cuts and rising pressure to return to in-office work have added to workplace malaise, Future Forum researchers said. Women and younger workers, in particular, reported struggling with burnout.

Regional pressures are also getting people down. In the UK, strikes have crippled the country as public-sector unions protest what they see as paltry pay increases. Japan’s government has asked firms there to help workers cope with the highest inflation since 1981. French citizens have taken to the streets to protest the government’s plan to raise the retirement age to 64 from 62, which could result in some concessions around working from home, a government spokesman said earlier this week.

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More than 40% of people with desk jobs feel burned out at work, a pandemic-era high, according to a survey.https://t.co/ygLR2uE8FI

— Bloomberg Law (@BLaw) February 15, 2023

Economists will spend hours poring over US inflation data released on Tuesday. But their calculations mostly obscure the experience of American families trying to make ends meet.

In 1985, an American man working the typical full-time job could support a family of four on 40 weeks of income, and be able to afford a range of nutritious foods, a three-bedroom house, a comprehensive health insurance plan, a family car, even saving to put both kids through the state university. In 2022, paying for all that would require 62 weeks of his income, which is a problem, there being only 52 weeks in a year.

These figures come from the Cost-of-Thriving Index (Coti), which compares the rate at which wages are rising to the rate of cost increases for middle-class staples. They show starkly the effect on household budgets of a decades-long stretch in which housing prices, health insurance premiums, college tuition, and more skyrocketed much faster than wages.

Traditional measures of inflation miss this fact. When inflation-adjusted figures report that a 2022 earner could afford roughly what a 1985 earner could, that assumes the 2022 earner still wants to drive a 1985 car, live in a 1985 house, watch a 1985 television, and receive 1985 medical care — and that we would call that “middle class”. 

Think about healthcare, where economists (rightly) celebrate extraordinary but costly breakthroughs in medical technology while families (also rightly) notice that insurance premiums keep eating a larger share of their salary.

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US inflation data is out today and economists will be poring over it. But their calculations hide the real experience of ordinary Americans trying to make ends meet, says Oren Cass https://t.co/01hAdmzLAo

— FT Opinion (@ftopinion) February 14, 2023

State laws tend to allow the gambling industry to regulate itself, which means that these companies are expected to identify and exclude their steadiest customers. This has been as unsuccessful as one might expect; as much as 50 percent of revenue comes from “problem gamblers,” while one study showed that in 1998, only 4 percent of gambling revenue from video lottery games came from “responsible” gamers. Just as tobacco companies would go out of business if people used their products responsibly, gambling wouldn’t be a multibillion-dollar industry if it weren’t for addicts.

Marijuana has a more complicated legacy, especially because it has real (but rather modest) benefits for medicinal use. However, careful analyses show that marijuana legalization has contributed to a rise in opioid-related deaths, especially when dispensaries can legally sell all sorts of cannabis products. Permitting dispensaries also increases referrals for addiction treatment, which is unsurprising considering that higher-potency products are more dangerous. The best evidence we have suggests that marijuana is harmful to teenage brains as they develop and that more teenagers use marijuana when it is legalized in their state.

The industries that profit off addiction want to frame the question of access around “responsible use” and occasionally suggest that some people might have a genetic predisposition to addiction. This individualistic framing allows them to avoid talking about how much effort they’re putting into making their products as accessible as possible. Even more important, it elides the question of whether we are all better off when it’s easier to start an addiction and harder to escape one.

There’s a richer and more compelling vision, one that is drawn from philosophical traditions across the ages. It recognizes that our life together isn’t merely a series of contracts we negotiate, and that our ability to make good decisions isn’t based simply on our rationality. Virtue is not simply doing good deeds, but also a set of dispositions and habits that must be practiced in order to flourish. Just as people can be sucked into addictions, we can also work to develop the virtues inside us so that we can be kind, generous, and self-controlled throughout our lives.

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America Has Gone Too Far in Legalizing Vice https://t.co/b8WnbgFO49

— Matt Lewis (@mattklewis) February 13, 2023

Valentyn Lymarenko and his infantry unit have already been seasoned by a year of combat, but they are grunting through exercises in this snowy trench to prepare for the next phase of fighting: a much-anticipated Russian offensive.

“We know they are coming,” Lymarenko said amid the pop of practice rifle fire. “We don’t know where.”

As Moscow struggles to turn the tide of a war that so far has largely failed, Ukrainians are bracing for a Kremlin do-over. But just where Russia will seek to land its blow remains a mystery, forcing Kyiv to ready its troops along a varied and forbidding front stretching from Belarus to the Black Sea.

From boggy northern wetlands to raging street fighting in the east to the treeless southern steppe, each range of terrain presents its own set of challenges and openings for Russian invaders and the Ukrainians intent on expelling them.Read it all.

Russian and Ukrainian forces dig into position for war’s next phase – The Washington Post

https://t.co/MI1MSnhsk2

— Mike Walker (@New_Narrative) February 9, 2023

Americans are more likely to predict negative rather than positive outcomes for five key aspects of the U.S. economy over the next six months. Higher inflation, unemployment and interest rates, as well as reduced economic growth and stock market values, are all expected.

A majority of U.S. adults (67%) expect inflation to rise, although more (79%) predicted that it would last year. At the same time, the public’s outlook for unemployment and the stock market have become more pessimistic and are now negative on balance. Expectations for economic growth and the stock market are the most pessimistic in Gallup’s periodic trend.

Gallup first asked Americans in October 2001 what they expected would happen with these five aspects of the economy and updated them monthly until 2006. Since then, Gallup has asked about them eight times, though not during the late 2007-early 2009 Great Recession. The latest results are from the Jan. 2-22 Mood of the Nation poll, which also found that Americans’ confidence in the economy remains low, mentions of inflation as the nation’s most important problem are still elevated and perceptions of the job market are positive but weakened compared with a year ago.

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Americans are more likely to predict worsening rather than improving conditions for five economic aspects, including inflation, unemployment, economic growth, the stock market and interest rates. https://t.co/xsV2WlFSyE

— GallupNews (@GallupNews) February 6, 2023

Here’s something odd: We’re getting worse at construction. Think of the technology we have today that we didn’t in the 1970s. The new generations of power tools and computer modeling and teleconferencing and advanced machinery and prefab materials and global shipping. You’d think we could build much more, much faster, for less money, than in the past. But we can’t. Or, at least, we don’t.

Throughout the 1950s and 1960s, productivity in the construction sector — how much more could be done given the same number of workers and machines and land — grew faster than productivity in the rest of the economy. Then, around 1970, it began to fall, even as economywide productivity kept rising. Today, the divergence is truly wild. A construction worker in 2020 produced less than a construction worker in 1970, at least according to the official statistics. Contrast that with the economy overall, where labor productivity rose by 290 percent between 1950 and 2020, or to the manufacturing sector, which saw a stunning ninefold increase in productivity.

In the piquantly titled “The Strange and Awful Path of Productivity in the U.S. Construction Sector,” Austan Goolsbee, the newly appointed president of the Chicago Federal Reserve and a former chairman of the Council of Economic Advisers, under President Barack Obama, and Chad Syverson, an economist at the University of Chicago’s Booth School of Business, set out to uncover whether this is all just a trick of statistics, and if not, what has gone wrong.

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A Really Good Piece: The Story Construction Tells About America’s Economy Is Disturbing https://t.co/4BEMy8ScKA

— Francis Fukuyama (@FukuyamaFrancis) February 6, 2023

Africa’s largest economy, Nigeria, is in the process of introducing new banknotes for the first time in more than 20 years. The move is an attempt to reignite confidence in the currency, the naira, which is under severe pressure. With inflation at more than 20%, people are struggling to cope with the rising cost of living. It is leading to the largest exodus of young professionals in years.

“Imagine going to the grocery store one day, and everything has tripled in price? How do you even cope? You have a family at home. What do you cut out of the budget?” Oroma Cookey Gam tells me by Zoom, her face incredulous.

The fashion designer left Nigeria’s biggest city, Lagos, with her young family a year ago for the UK capital, London. Her husband and business partner Osione, an artist, was granted a Global Talent visa, which enables leaders in academia, arts and culture, as well as digital technology to work in the UK.

She says it had become too expensive to raise their young family in Lagos. “Our money was buying us less and less. We weren’t able to pay our bills, we weren’t able to do normal things that we were doing.”

Oroma studied law at the UK’s University of Northumbria and moved back to Nigeria almost 20 years ago, keen to use her degree to help develop her country. Along with Osione, she eventually set up This Is Us, a sustainable fashion and lifestyle brand that uses local materials and artisans, including cotton grown and dyed in northern Nigeria.

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Important piece.

“Despite having one of the largest health workforces on the continent, Nigeria's skilled health workforce density is only 1.95/1,000 population, well below the recommended benchmark”.

On brain drain @MayeniJones https://t.co/O9banuAPIw

— Ashis Basu (@BasuAshis) January 31, 2023