The Death Spiral is one of the main Pentagon Pathologies. The American people devote ever greater resources to their defense while receiving less and less in return. The Air Force had 10,387 aircraft in 1975 when the Military Reformers began their work in earnest. Today the Air Force has 5,288. The Navy had 559 active ships in 1975. Today the fleet has only 296. The Pentagon’s base budget is more than 60% higher today than it was in 1975, when adjusted for inflation. The American people simply spend more and receive much less in return for their defense dollars.

An argument can be made that modern military equipment is more expensive because of the capabilities they provide the troops. That is extremely debatable because many of the high-profile acquisition programs over the past 25 years have been underwhelming at best, and often complete failures. It is difficult to find anyone who will honestly say the Littoral Combat Ship was worth the effort.

Left unchecked, the acquisition Death Spiral’s inevitable destination is unilateral disarmament. Norman Augustine, a former DoD official and Lockheed Martin CEO predicted in 1983, with only a hint of satire, that by 2054, “the entire defense budget will purchase just one aircraft. This aircraft will have to be shared by the Air Force and Navy 3-1/2 days each per week except for leap year, when it will be made available to the Marines for the extra day.”

Read it all.

At the current spending rate, in another generation we will have a lot of rich contractors and no aircraft or Naval fleets to speak of https://t.co/k4XV5gsk7Z

— Responsible Statecraft (@RStatecraft) October 24, 2024

The action is now moving beyond America. With over two-fifths of the world overweight or obese, demand for glp-1 drugs is voracious. Pharma companies are racing to make them work as pills, which would be cheaper to produce than jabs, and to reduce their side-effects. Generic versions for older GLP-1 agonists are entering the market. Semaglutide is to come off patent in Brazil, China and India in 2026; eight such drugs are in the works in China. That is just as well. As incomes in the developing world have risen and life has become more sedentary, people’s waistlines are catching up with those in the West.

Curbing obesity would be consequential. Yet glp-1 drugs promise to do much more. Overweight patients on semaglutide have been found to suffer fewer heart attacks and strokes; the benefits, astonishingly, seem to be largely independent of how much weight is lost. Tirzepatide improves sleep apnoea. Trials show that glp-1 agonists reduce chronic kidney disease in diabetics; and there are signs they may lessen brain shrinkage and cognitive decline in Alzheimer’s. Studies of health records suggest that they may help with addictions, too; people already on glp-1 drugs in America were less likely to overdose on opioids or abuse cannabis or alcohol. Researchers are even talking, in hushed tones, of their anti-ageing effects.

How can one class of drug do so much? As our briefing explains this week, not only do the drugs act in the gut, but they also bind to receptors all over the body and in the brain. 

Read it all.

I’ve been saying this for quite some time: GLP-1 agonists are miracle “everything drugs”! it’s likely there’ll be more of these types of drugs soon

“It’s not just obesity. Drugs like Ozempic will change the world
As they become cheaper, they promise to improve billions of lives” pic.twitter.com/61tc17dKRE

— Derya Unutmaz, MD (@DeryaTR_) October 24, 2024

Inflation seems under control. The job market remains healthy. Wages, including at the bottom end of the scale, are rising. But this is just a lull. There is a storm approaching, and Americans are not prepared.

Barreling toward us are three epochal changes poised to reshape the U.S. economy in coming years: an aging population, the rise of artificial intelligence and the rewiring of the global economy.

There should be little surprise in this, since all these are evolving slowly in plain sight. What has not been fully understood is how these changes in combination are likely to transform the lives of working people in ways not seen since the late 1970s, when wage inequality surged and wages at the low end stagnated or even fell.

Together, if handled correctly, these challenges could remake work and deliver much higher productivity, wages and opportunities — something the computer revolution promised and never fulfilled. If we mismanage the moment, they could make good, well-paying jobs scarcer and the economy less dynamic. Our decisions over the next five to 10 years will determine which path we take.

Read it all.

America is sleepwalking into an economic storm.
— Daron Acemoglu

GIFT ARTICLE

Barreling toward us are three epochal changes poised to reshape our economy: an aging population, the rise of artificial intelligence and the rewiring of the global economy.https://t.co/pf82B0DE9N

— Walter Appling (@WalterAppling) October 17, 2024

Codi Hamilton and Marina Harrison met in virtual reality (VR) — putting on headsets and entering an arena of infinite possibilities. The couple are part of a growing trend for real-life relationships to begin not just online, but virtually….

Hamilton, 30, said the [new] model would be a game-changer. “This will introduce more people into virtual reality, considering that the biggest issue is the price point,” he said. “A more affordable headset will likely sway a lot of people to try VR for the first time.”

Hamilton and Harrison run a business organising parties in VR, where performers entertain audiences with acrobatics, pole dancing and DJ sets, all in their own homes. People can go on VR “dates” to theme parks, bars and landmarks around the world, or get married in virtual ceremonies. Some even spend the night sleeping with their headsets on, although most said the contraptions were too cumbersome to be comfortable enough to doze off.

Read it all (subscription).

‘His avatar was kind of cute’ — meet the couples who fell in love in VR https://t.co/z6OoJY2kOZ pic.twitter.com/bB7UXPGfk8

— The Times and The Sunday Times (@thetimes) October 15, 2024

TV presenter and conservationist Chris Packham has led calls to the Church of England to commit to re-wilding 30 per cent of its land. 

The call is backed by high profile figures including former Archbishop of Canterbury, Rowan Williams, former cabinet minister Michael Gove, and actor and broadcaster Stephen Fry, as well as 100,000 members of the public. 

The campaign, by the Wild Card group, was launched on the steps of St Paul’s Cathedral in London, where Packham unravelled the ’95 Wild Theses’ – a spin on Martin Luther’s Ninety-five Theses that triggered the Protestant Reformation. 

Read it all.

Chris Packham leads calls to rewild Church of England https://t.co/4f3SxzEfvE

— Sharon K. Gilbert (@sharonkgilbert) October 8, 2024

“Nuclear Nightmare,” screamed the headline in Time magazine on April 9th 1979. One of the two reactors at a nuclear-power plant at Three Mile Island in Pennsylvania had suffered an accident. The governor ordered an evacuation of all vulnerable people within five miles of the plant as radioactive gas escaped.

In the end, the accident resulted in no injuries or loss of life. Two decades later, The Economist visited the Pennsylvania hinterlands and found the second, unproblematic reactor still running well and enjoying strong local support. It cranked out power until it was mothballed in 2019 owing not to safety concerns but to competition from cheap shale gas.

Now Three Mile Island is coming back from the dead. On September 20th Microsoft, a tech giant, and Constellation Energy, the utility that decommissioned the trouble-free reactor, signed a deal to return it to service. The utility will spend about $1.6bn to restore the plant by 2028. Microsoft will then buy its carbon-free power for the next 20 years.

Read it all.

Great look at how Big Tech is leveraging its market power and analytics to shift more project risk onto renewable energy developers:https://t.co/n3MsUpHbnj

— Lee Harris (@leee_harris) October 8, 2024

Traditional methods of diagnosing mental-health conditions require patients to speak directly to a psychiatrist. Sensible in theory, such assessments can, in practice, take months to schedule and ultimately lead to subjective diagnoses.

That is why scientists are experimenting with ways to automate this process. Artificial-intelligence (AI) tools trained to listen to patients have proved capable of detecting a range of mental-health conditions, from anxiety to depression, with accuracy rates exceeding conventional diagnostic methods.

By analysing the acoustic properties of speech, these AI models can identify markers of depression or anxiety that a patient might not even be aware of, let alone able to articulate. Though individual features like pitch, tone and rhythm each play a role, the true power of these models lies in their ability to discern patterns imperceptible to a psychiatrist’s ears.

Read it all.

For overburdened clinicians, speech analysis conducted by AI models could help triage patients and offer continuous monitoring for those requiring at-home treatments https://t.co/3XzKx6IR04

Illustration: Mark Pernice pic.twitter.com/Ct639aO9Yr

— The Economist (@TheEconomist) October 4, 2024

As flooding hammered Appalachia in the aftermath of Hurricane Helene, residents became intimately familiar with a new norm in the US’s post-storm script: dams at imminent risk of failing.

Officials last week said multiple dams were on the brink, including Tennessee’s Nolichucky Dam and North Carolina’s Walters and Lake Lure dams. People in nearby communities were ordered to evacuate.

Ultimately, the dams held. But the close calls highlighted the stress on the nation’s dams, many of which are more than half a century old and none of which were designed for the higher levels of precipitation brought on by climate change.

Read it all.

American Dams Weren’t Built for Today’s Climate-Charged Rain and Floods – BNN Bloomberg https://t.co/plyeQFSzZE @americanrivers

— Aric Caplan (@Aric_Advocates) October 2, 2024

North Korea this month lifted the veil on one of its most closely guarded nuclear secrets, releasing the first public photos of centrifuges it uses to make bomb-grade uranium. The revelatory images of North Korean leader Kim Jong Un touring a vast centrifuge hall, along with the recent startup of a reactor that may be producing plutonium and tritium for atomic weapons, heighten concerns over the rogue nation’s growing arsenal. They also help bring its nuclear program into sharper focus.

Kim’s nuclear whistle stop, which also included images of a smaller centrifuge hall, follows a speech in which he reiterated a 2023 vow to “exponentially” increase his nuclear stockpile. He has suggested the effort will include large numbers of tactical nuclear weapons, lower yield devices designed for short- or medium-range missiles. “North Korea is deadly serious about deploying large numbers of tactical nuclear weapons,” says Jeffrey Lewis, a North Korea expert at the James Martin Center for Nonproliferation Studies. Tactical nukes would pose an especially grave threat to neighboring South Korea.

Read it all.

Photos open rare window into North Korea’s nuclear weapons program | Science | AAAS https://t.co/qnBMibdPIh

— Amb Antonio Garza (@aogarza) September 24, 2024

Some 13.8 billion years ago, the universe began in a big bang – or, at least, that is what we think happened. Astrophysicist Jo Dunkley is at the forefront of efforts to work out exactly what took place in the immediate aftermath of that moment of cosmic creation. And a new telescope might just help her answer this question once and for all.

The issue with the big bang is that we can’t see it directly. The best we can do is look at the cosmic microwave background (CMB), often called the afterglow of the big bang. Faintly daubed across the whole sky, this radiation is all that is left of the first light that could travel in the universe. Subtle patterns in this light fit with the well-established idea that the big bang was followed by a period known as inflation, when the universe expanded at a rip-roaring pace. But it has never been proven.

Dunkley, who is based at Princeton University, thinks that observing the CMB in finer detail than ever before will clinch the deal, specifically by helping us see patterns imprinted by gravitational waves from the dawn of time. To glimpse these, she plans to use the Simons Observatory, a purpose-built telescope in Chile that is on the cusp of switching on.

Read it all.

Through @simonsobs, #PrincetonU's @j_dunkley hopes to find out just what happened in the immediate aftermath of the Big Bang. https://t.co/sCvIfJuRIq

— Princeton University (@Princeton) September 23, 2024

Allison Jumper’s family was a picture of healthy living. Active kids. Wholesome meals. A freezer stocked with organic beef from her in-laws’ farm in Maine.

Then in late 2020, she got a devastating call from her brother-in-law. High levels of harmful “forever chemicals” had been detected on their farm and in their cows’ milk, and they were getting shut down.

At first, Mrs. Jumper worried only about her in-laws’ livelihoods. But soon, her mind went somewhere else: to her own children’s mysterious health issues, including startlingly high cholesterol levels.

“Then it hit me,” she said at her home in Durham, N.H. “Could it be the beef?”

Read it all.

Her family’s farm was hiding dangerous chemicals in their food https://t.co/6aYN9OtCNW

— Judith Enck (@enckj) September 23, 2024

Climate optimism is fading. Higher costs, pushback from businesses and consumers, and the slow rollout of technology are delaying the transition from fossil fuels.

Renewable energy is growing faster than expected. But surging demand for power is sucking up much of that additional capacity and forcing utilities to burn fossil fuels, including coal, for longer than expected.

With greenhouse-gas emissions continuing at record levels, scientists expect floods and heat waves to get worse. This year is on track to be the hottest on record.

“The pace of our response is obviously totally insufficient,” said Sonia Seneviratne, a climate scientist at Swiss university ETH Zurich. On this trajectory, “it will become increasingly impossible to face the changing climate we are going to experience,” she said.

Read it all.

Climate optimism is fading as high costs and new priorities like AI push the energy transition down the priority list for businesses and investors. Climate week story taking stock of the setbacks w/ @edmballard:https://t.co/7tZDL7w0Sd

— Amrith Ramkumar (@AmrithRamkumar) September 23, 2024

Further tens of millions of pounds are to be pumped into efforts to drastically reduce the Church of England’s carbon emissions over the next six years, the first impact report on its net-zero programme says.

The report summarises progress on the General Synod’s ambition to achieve net zero by 2030, which was set in 2020 (News, 12 February 2020). The Synod approved a “route map” to this goal two years later (News, 15 July 2022).

In real terms, the target is to decrease the Church’s emissions — mainly from its buildings — by 90 per cent against the current baseline: 415,000 tonnes of carbon-dioxide equivalent (415,000T CO2e). The remaining ten per cent is to be offset by carbon-cancelling schemes, such as tree-planting and installing solar panels.

Read it all.

Further tens of millions of pounds are to be pumped into efforts to drastically reduce the Church of England’s carbon emissions over the next six years, the first impact report on its net-zero programme says https://t.co/GlXOa0tBpM pic.twitter.com/NAkFHUtMIL

— Church Times (@ChurchTimes) September 19, 2024

The FBI said on Wednesday that it had disrupted a Chinese hacking group nicknamed “Flax Typhoon”  that targeted critical infrastructure in the United States.

The Flax Typhoon hackers installed malicious software on thousands of computers and other internet-connected devices including cameras, video recorders and routers.

This created a botnet — a massive network of infected computers.

Universities, government agencies, telecommunications providers, media organizations and NGOs were among the targets, the FBI said.

“Flax Typhoon’s actions caused real harm to its victims, who had to devote precious time to clean up the mess when they discovered the malware,” said FBI director Chris Wray.

Read it all.

A hacker group known as Flax Typhoon was able to infect hundreds of thousands of devices around the world, authorities said. China has denied any involvement in the malicious botnet.https://t.co/FoeAA9IPMg

— DW News (@dwnews) September 19, 2024

Norway is the first country in the world with more electric vehicles than gas-powered cars on the road, according to vehicle registration data the Norwegian road federation, known as OFV, released Tuesday.

Of the 2.8 million passenger cars registered in the country, 26.3 percent are fully electric, just edging out the share of gas vehicles. Diesel remains the most common vehicle type, making up more than a third of Norwegian vehicle registrations.

“The electrification of the passenger car fleet is keeping a high pace, and Norway is moving rapidly towards becoming the first country in the world with a passenger car fleet dominated by electric cars,” OFV Director Oyvind Solberg Thorsen saidin a statement. He predicted EVs will outnumber diesel cars by 2026.

Read it all.

Save you a click: Norway.
This country is now the world’s first to have more EVs than gas-powered cars https://t.co/WkVNxqxAlv

— Jeff (Gutenberg Parenthesis) Jarvis (@jeffjarvis) September 18, 2024

Researchers at the University of Waterloo have designed an energy-efficient device that produces drinking water from seawater using an evaporation process driven largely by the sun.

Desalination is critical for many coastal and island nations to provide access to fresh water, given water scarcity concerns due to rapid population growth and increasing global water consumption. Roughly 2.2 billion people worldwide have no access to clean water, emphasizing the urgent need for new technologies to generate fresh water, according to the UN World Water Development Report 2024.

Current desalination systems pump seawater through membranes to separate salt from water, but this process is energy-intensive, and salt often accumulates on the device’s surface, obstructing water flow and reducing efficiency. As a result, these systems require frequent maintenance and cannot operate continuously.

To solve this problem, Waterloo researchers drew inspiration from the natural water cycle to create a device that mirrors how trees transport water from roots to leaves. The new technology can continuously desalinate water without the need for major maintenance.

Read it all.

Solar device makes 20L drinking water a day from seawater with 93% efficiencyhttps://t.co/PrkqDvzdh7

— Interesting Engineering (@IntEngineering) September 12, 2024

Geothermal energy may be approaching its Mitchell moment. George Mitchell, a scrappy independent oilman, is known as the father of fracking. Nearly three decades ago, he defied Big Oil and the conventional wisdom of his industry by making practical the hitherto uneconomic technique of pumping liquids and sands into the ground to force out gas and oil from shale rock and other tight geological formations. The enormous increase in productivity that resulted, known as the shale revolution, has transformed the global hydrocarbon business.

Now Fervo Energy, another scrappy Texan upstart, is applying such hydraulic fracturing—alongside other techniques borrowed from the petroleum industry—to the sleepy geothermal sector. Should it succeed, it would mean this relatively fringe source of energy could, in time, become a major player in the energy mix.

The motivation behind geothermal energy is to harness Earth’s abundant subsurface heat for useful ends. This is ordinarily done by tapping into underground reservoirs of hot water or steam. As these are only found in limited areas, this greatly limits the potential of conventional geothermal power. In contrast, “enhanced geothermal systems” (EGS), like the one deployed by Fervo, use hydraulic stimulation to create channels in hot rocks just about anywhere. One well pumps in water into those channels, where it is heated naturally to 200°C or higher. Another well then brings that hot water to the surface, where it is used to generate electricity in a turbine….

Read it all.

Geothermal energy is usually harvested by tapping into underground reservoirs of hot water or steam. These are only found in limited areas, this greatly limits the potential of conventional geothermal power.

There has been a hot-rocks breakthrough https://t.co/5VDAvYpUIq

— The Economist (@TheEconomist) September 15, 2024

OpenAI’s latest models have “meaningfully” increased the risk that artificial intelligence will be misused to create biological weapons, the company has acknowledged.

The San Francisco-based group announced its new models, known as o1, on Thursday, touting their new abilities to reason, solve hard maths problems and answer scientific research questions.

These advances are seen as a crucial breakthrough in the effort to create artificial general intelligence — machines with human-level cognition. OpenAI’s system card, a tool to explain how the AI operates, said the new models had a “medium risk” for issues related to chemical, biological, radiological and nuclear (CBRN) weapons — the highest risk that OpenAI has ever given for its models. The company said it meant the technology has “meaningfully improved” the ability of experts to create bioweapons.

Read it all (subscription).

OpenAI acknowledges new models increase risk of misuse to create bioweapons https://t.co/tFJOhIwPEm via @ft

— Anjana Susarla (@asusarla) September 15, 2024

Telegram has become a global sewer of criminal activity, disinformation, child sexual abuse material, terrorism and racist incitement, according to a four-month investigation by The New York Times that analyzed more than 3.2 million Telegram messages from over 16,000 channels. The company, which offers features that enable criminals, terrorists and grifters to organize at scale and to sidestep scrutiny from the authorities, has looked the other way as illegal and extremist activities have flourished openly on the app.

The degree to which Telegram has been inundated by such content has not been previously reported. The Times investigation found 1,500 channels operated by white supremacists who coordinate activities among almost one million people around the world. At least two dozen channels sold weapons. In at least 22 channels with more than 70,000 followers, MDMA, cocaine, heroin and other drugs were advertised for delivery to more than 20 countries.

Hamas, ISIS and other terror groups have thrived on Telegram, often amassing large audiences across dozens of channels. The Times analyzed more than 40 channels associated with Hamas, which showed that average viewership surged up to 10 times after the Oct. 7 attacks, garnering more than 400 million views in October.

Telegram is “the most popular place for ill-intentioned, violent actors to congregate,” said Rebecca Weiner, the deputy commissioner for intelligence and counterterrorism at the New York Police Department. 

Read it all.

Must read investigation: How Telegram Became a Playground for Criminals, Extremists and Terrorists. Drug dealers, scammers and white nationalists openly conduct business and spread toxic speech on the platform.https://t.co/iw9tYGuirV

— Farnaz Fassihi (@farnazfassihi) September 7, 2024

Seeing what’s going on inside a body is never easy. While technologies like CT scans, X-rays, MRIs, and microscopy can provide insights, the images are rarely completely clear and can come with side effects like radiation exposure. 

But what if you could apply a substance on the skin, much like a moisturizing cream, and make it transparent, without harming the tissue? 

That’s what Stanford scientists have done using an FDA-approved dye that is commonly found in food, among several other light-absorbing molecules that exhibit similar effects. Published in Science on Sept. 5, the research details how rubbing a dye solution on the skin of a mouse in a lab allowed researchers to see, with the naked eye, through the skin to the internal organs, without making an incision. And, just as easily as the transparency happened, it could be reversed.

“As soon as we rinsed and massaged the skin with water, the effect was reversed within minutes,” said Guosong Hong, assistant professor of materials science and engineering and senior author on the paper. “It’s a stunning result.” 

Read it all.

Read about really creative and innovative research from my colleagues @HongNeuroTech and @BrongersmaMark : a common food dye can make your skin transparent!https://t.co/aizYD8Xnv0

— Alberto Salleo (@asalleo) September 5, 2024

Cyber attacks pose a risk as big as terrorism and flooding, according to two of the world’s biggest insurance groups that are calling for state support to help the industry to absorb losses. 

Insurer Zurich and Marsh McLennan, the world’s biggest insurance broker, say in a new report that cyber threats are “outpacing the ability of traditional insurance and risk management approaches to fully mitigate them”.  There are “limits to the amount of financial loss” the private sector can absorb, the report says, given the potentially huge losses that could be caused by a cyber attack on critical infrastructure.

It proposes a number of steps to address this, including creating public-private partnerships to share losses from currently “uninsurable” events, such as a cyber attack that causes a widespread failure of key infrastructure.

Read it all (subscription).

Insurance groups urge state support for ‘uninsurable’ cyber risks https://t.co/H2zrEsMrLY

— Finance News (@ftfinancenews) September 4, 2024

The British biologist J. B. S. Haldane once quipped that “there is no great invention, from fire to flying, which has not been hailed as an insult to some god”. The concept of “playing God” is a well-known cultural trope. For most people the phrase implies Promethean hubris, an arrogant overextension of human capabilities and ambitions beyond what is appropriate, potentially leading to unforeseen and uncontrollable consequences. But who decides what humanity’s “proper” limits might be? Might the quest for a deeper understanding of our world be an act of service, aimed at safeguarding our world on the one hand and promoting human flourishing on the other?

Playing God: Science, religion and the future of humanity by Nick Spencer and Hannah Waite offers an engaging and helpful overview of the contemporary debates on these themes. Both writers are associated with the London-based Theos think tank, which hosts public debates, discussions and lectures about religion and society. Although the theme of “playing God” is emphasized in the work’s main title, its focus is better seen as an exploration of the interaction of science and religion in discussing a series of questions raised, but not answered, by technological advance.

Read it all.

'The question shifts from whether we should play at being God to how we should do this.'

Alister McGrath (@alisteremcgrath) on what theology might teach us about technological hubris
https://t.co/KsRh8JBYti

— The TLS (@TheTLS) August 23, 2024

….a better diet for pregnant mothers and infants would eventually make humanity more intelligent. Alas, child malnutrition is far from being eradicated—and not just in poor, war-charred places like Congo. Many middle-income countries also have shockingly high rates.

How much of a cognitive boost would the world get from feeding babies better? Precision is tricky, but scientists agree it would be huge. If a fetus’s weight is below the tenth percentile, the child can expect to score half a standard deviation worse on all neuro-developmental measures—the rough equivalent of seven iq points. After birth, the speeds at which a baby puts on weight (before four months) and length (before 12 months) are good predictors of iq at the age of nine. A study in Bangladesh found that the combination of malnutrition and inadequate stimulation common in poor families was associated with an iq gap of a whole standard deviation (about 15 points) by the age of five.

Even if a baby has enough macronutrients (protein, carbohydrates and fat), its brain development can be hobbled by a lack of micronutrients such as iron, iodine or zinc. Yet such deficiencies remain rife: half the world’s young children and two-thirds of women of reproductive age do not get enough micronutrients. For brain development, the most serious shortfall is iron. Two-fifths of children aged 6-59 months were anaemic (iron deficient) in 2019. Between 2012 and 2019, at least 92 countries saw no improvement on this score, laments Dr Shekar.

Read it all.

The cover of @TheEconomist this week: Small investments in nutrition could make the world brainier pic.twitter.com/kEsSdAieMt

— alain servais (@aservais1) July 12, 2024

In 2018 an international team of scientists — from labs in Houston, Copenhagen, Barcelona and beyond — got their hands on a remarkable biological specimen: a skin sample from a 52,000-year-old woolly mammoth that had been recovered from the permafrost in Siberia. They probed the sample with an innovative experimental technique that revealed the three-dimensional architecture of the mammoth’s genome. The resulting paper was published on Thursday in the journal Cell.

Hendrik Poinar, an evolutionary geneticist at McMaster University in Canada, was “floored” — the technique had successfully captured the original geometry of long stretches of DNA, a feat never before accomplished with an ancient DNA sample. “It’s absolutely beautiful,” said Dr. Poinar, who reviewed the paper for the journal.

The typical method for extracting ancient DNA from fossils, Dr. Poinar said, is still “kind of cave man.” It produces short fragments of code composed of a four-letter molecular alphabet: A (adenine), G (guanine), C (cytosine), T (thymine). An organism’s full genome resides in cell nuclei, in long, unfragmented DNA strands called chromosomes. And, vitally, the genome is three-dimensional; as it dynamically folds with fractal complexity, its looping points of contact help dictate gene activity.

“To have the actual architectural structure of the genome, which suggests gene expression patterns, that’s a whole other level,” Dr. Poinar said.

Read it all.

My latest for @Nature: On Siberia's frozen tundra some 50,000 years ago, a woolly mammoth met its end. In the animal’s skin, researchers have now discovered chromosomes preserved in their original 3D shape—a feat previously thought impossible https://t.co/zr1mvj10h7

— Giorgia Guglielmi (she/her) (@GiorgiaWithAnI) July 11, 2024

An artificial intelligence (AI) model that speaks the language of proteins — one of the largest yet developed for biology — has been used to create new fluorescent molecules.

The proof-of-principle demonstration was announced this month by EvolutionaryScale in New York City, alongside US$142 million in new funding to apply its model to drug development, sustainability and other pursuits. The company, launched by scientists who previously worked at tech giant Meta, is the latest entrant in an increasingly crowded field that is applying cutting-edge machine-learning models trained on language and images to biological data.

“We want to build tools that can make biology programmable,” says Alex Rives, the company’s chief scientist, who was part of Meta’s efforts to apply AI to biological data.

Read it all.

“We want to build tools that can make biology programmable”
Ex-Meta scientists debut gigantic AI protein design model https://t.co/RJnpoLmVGJ

— Magdalena Skipper (@Magda_Skipper) July 8, 2024

The £5.2m Demonstrator Churches project from the Church of England’s Net Zero Programme aims to help 114 churches in 2024 and 2025 pay for items such as solar panels, heat pumps, insulation, secondary glazing, LED lighting and infrared heating systems.

As work progresses, the network of Demonstrator Churches – representing many different types of community and situations – will share what they have learned more widely with dioceses and parishes so that all Church of England churches can learn from their experiences.

Abi Hiscock, Project and Grants Manager for the Church of England’s Net Zero Demonstrator Churches Project, said: “Ultimately, we want to demonstrate that with the right support and infrastructure, churches from diverse settings and facing a variety of challenges can reach net zero by 2030.

“By the end of this project, we will have over 100 case studies on what to do and when, and what not to do. Along the way, the supported churches are all required to act as champions to other churches in their dioceses or geographically near to them, or simply to other churches working from similar baselines to them, so that the learnings from these projects engage, influence and support this vision.”

Read it all.

@StPeterMancroft is 1st of over 100 churches 2 receive part of the £5.2M Demonstrator Churches project from the Church of England’s Net Zero Programme.

Watch our journey towards net zero in the full video on the Diocese website. Here's a snippet…https://t.co/dsrNh10sAr

— VergerStPeterMancroft (@verger_st) July 4, 2024

One of North America’s largest areas of interconnected glaciers is melting twice as quickly as it did before 2010, a team of scientists said Tuesday, in what they called an “incredibly worrying” sign that land ice in many places could disappear even sooner than previously thought.

The Juneau Ice Field, which sprawls across the Coast Mountains of Alaska and British Columbia, lost 1.4 cubic miles of ice a year between 2010 and 2020, the researchers estimated. That’s a sharp acceleration from the decades before, and even sharper when compared with the mid-20th century or earlier, the scientists said. All told, the ice field has shed a quarter of its volume since the late 18th century, which was part of a period of glacial expansion known as the Little Ice Age.

As societies add more and more planet-warming carbon dioxide to the atmosphere, glaciers in many areas could cross tipping points beyond which their melting speeds up rapidly, said Bethan Davies, a glaciologist at Newcastle University in England who led the new research.

“If we reduce carbon, then we have more hope of retaining these wonderful ice masses,” Dr. Davies said. “The more carbon we put in, the more we risk irreversible, complete removal of them.”

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Study Finds Alaskan Ice Field Melting at an ‘Incredibly Worrying’ Pace https://t.co/MjBzzo3n4G

— Sarah Pickman (is also on Bluesky) (@sarahmpicks) July 3, 2024

Scientists like [Magdalena] Osburn have shown that, contrary to long-held assumptions, Earth’s interior is not barren. In fact, a majority of the planet’s microbes, perhaps more than 90 percent, may live deep un­derground. These intraterrestrial microbes tend to be quite different from their counterparts on the surface. They are ancient and slow, re­producing infrequently and possibly living for millions of years. They often acquire energy in unusual ways, breathing rock instead of oxy­gen. And they seem capable of weathering geological cataclysms that would annihilate most creatures. Like the many tiny organisms in the ocean and atmosphere, the unique microbes within Earth’s crust do not simply inhabit their surroundings; they transform them. Subsurface microbes carve vast caverns, concentrate minerals and precious metals and regulate the global cycling of carbon and nutrients. Microbes may even have helped construct the continents, literally laying the ground­work for all other terrestrial life.

Like so much about Earth’s earliest history, exactly where and when life first emerged is not definitively known. At some point not long after our planet’s genesis, in some warm, wet pocket with the right chemistry and an adequate flow of free energy — a hot spring, an impact crater, a hydrothermal vent on the ocean floor — bits of Earth rearranged themselves into the first self-replicating entities, which eventually evolved into cells. Evidence from the fossil record and chemical analysis of the oldest rocks ever discovered indicate that microbial life existed at least 3.5 billion years ago and possibly as far back as 4.2 billion years ago.

Among all living creatures, the peculiar microbes that dwell deep within the planet’s crust today may most closely resemble some of the earliest single-celled organisms that ever existed. Collectively, these subsurface microbes make up an estimated 10 to 20 percent of the biomass — that is, all the living matter — on Earth. Yet until the mid-20th century, most scientists did not think subterranean life of any kind was plausible below a few meters.

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We know SO little about our earth. Many wonderful quotable passages. An important article.

The Mysterious, Deep-Dwelling Microbes That Sculpt Our Planet https://t.co/vh4XXYNIgW

— sammyzorba (@sammyzorba) June 25, 2024

Oceans help cool down the world. Startups are betting they can tweak the chemistry of seas to make them do even more.

It is a radical idea that has yet to be proven on a commercial scale and causes some to worry about potential risks. But at least a dozen young companies are embarking on the world’s first major projects to get oceans to soak up more carbon dioxide, encouraged by billions of dollars in federal and corporate funding for efforts that remove the greenhouse gas from the atmosphere.

A startup that uses an electrochemical method to remove carbon from seawater is building its first commercial-scale plants in Singapore and Quebec. Removing the carbon boosts the ocean’s ability to soak up more from the atmosphere. The U.S. government recently awarded it and a competitor with a similar approach some of the first federal funding for carbon removal. 

Another startup is set to pour about 9,000 tons of sand mixed with a yellow-green mineral called olivine near the waters off North Carolina’s Outer Banks. When the sand dissolves in water, it triggers a series of chemical reactions that drive carbon removal.

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Oceans absorb about 30% of the carbon from the atmosphere. Startups are developing technologies to rev up that power. https://t.co/oM5JP6VR7H via @WSJ

— WSJ Science (@WSJscience) June 25, 2024

Researchers and activists in the trenches of the long fight against H.I.V. got a rare piece of exciting news this week: Results from a large clinical trial in Africa showed that a twice-yearly injection of a new antiviral drug gave young women total protection from the virus.

“I got cold shivers,” said Dr. Linda-Gail Bekker, an investigator in the trial of the drug, lenacapavir, describing the startling sight of a line of zeros in the data column for new infections. “After all our years of sadness, particularly over vaccines, this truly is surreal.”

Yvette Raphael, the leader of a group called Advocacy for Prevention of H.I.V. and AIDS in South Africa, said it was “the best news ever.”

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