Category : Health & Medicine

(MIT News) Researchers improve blood tests’ ability to detect and monitor cancer

Tumors constantly shed DNA from dying cells, which briefly circulates in the patient’s bloodstream before it is quickly broken down. Many companies have created blood tests that can pick out this tumor DNA, potentially helping doctors diagnose or monitor cancer or choose a treatment.

The amount of tumor DNA circulating at any given time, however, is extremely small, so it has been challenging to develop tests sensitive enough to pick up that tiny signal. A team of researchers from MIT and the Broad Institute of MIT and Harvard has now come up with a way to significantly boost that signal, by temporarily slowing the clearance of tumor DNA circulating in the bloodstream.

The researchers developed two different types of injectable molecules that they call “priming agents,” which can transiently interfere with the body’s ability to remove circulating tumor DNA from the bloodstream. In a study of mice, they showed that these agents could boost DNA levels enough that the percentage of detectable early-stage lung metastases leapt from less than 10 percent to above 75 percent.

Read it all.

Posted in Health & Medicine, Science & Technology, Uncategorized

(WSJ) Chinese Lab Mapped Deadly Coronavirus Two Weeks Before Beijing Told the World, Documents Show

Chinese researchers isolated and mapped the virus that causes Covid-19 in late December 2019, at least two weeks before Beijing revealed details of the deadly virus to the world, congressional investigators said, raising questions anew about what China knew in the pandemic’s crucial early days.

Documents obtained from the U.S. Department of Health and Human Services by a House committee and reviewed by The Wall Street Journal show that a Chinese researcher in Beijing uploaded a nearly complete sequence of the virus’s structure to a U.S. government-run database on Dec. 28, 2019. Chinese officials at that time were still publicly describing the disease outbreak in Wuhan, China, as a viral pneumonia “of unknown cause” and had yet to close the Huanan Seafood Wholesale Market, site of one of the initial Covid-19 outbreaks.

China only shared the virus’s sequence with the World Health Organization on Jan. 11, 2020, according to U.S. government timelines of the pandemic.

The new information doesn’t shed light on the debate over whether Covid emerged from an infected animal or a lab leak, but it suggests that the world still doesn’t have a full accounting of the pandemic’s origin.

Read it all.

Posted in China, Health & Medicine, History

James Mitchell Petersen II RIP

Mitch was diagnosed with glioblastoma, an aggressive form of brain cancer, on his 40th birthday (September, 2021) when vacationing in Portugal. He was rushed to the United States to seek treatment at the Medical University of South Carolina (MUSC) in Charleston and to be with his family. During his 27-month long journey, he fought for his life seeking many types of treatments as well as traveling to Germany for a custom vaccine, consulting with doctors at Dana- Farber Cancer Institute in Boston and at Duke’s Brain Cancer Center in North Carolina. Mitch’s persistent personality and determination to battle this cancer while continuing to maintain his routine and quality of life helped him to outlive the average glioblastoma patient. While undergoing treatment, he was quick to re-kindle time and make memories with family and friends.

Through his cancer journey Mitch became a strong Christian and was baptized. He became active at the Church of the Holy Cross on Daniel Island forming strong relationships with the community and men’s life group. Mitch wrote his testimony about his journey to Christianity and was passionate about sharing it with others. Through his ministry he reached many people sharing what he learned from his life and the message that it is never too late to seek God.

Mitch is survived by his parents, Jim and Wanda Petersen; his sister, Rebecca Petersen Leddy; his brother-in-law, Lee Leddy; his nephew, Logan Leddy; his nephew, Connor Leddy; his niece, Sophia Leddy; and his aunt, Sandra Garrison.

Read it all.

Posted in * Anglican - Episcopal, * South Carolina, Children, Death / Burial / Funerals, Health & Medicine, Marriage & Family, Parish Ministry

This is a must not miss–The Heartwarming moment Heung-Min Son surprises a fan family who are going through very hard times

Posted in Children, England / UK, Health & Medicine, Marriage & Family, South Korea, Sports

(The Critic) Henry George–Euthanasia is liberalism’s endpoint

It is unsurprising that euthanasia consistently breaks its boundaries, always presented as an expansion of choice as the route to kindness. This is rooted in liberalism’s fundamental presuppositions, for as George Grant wrote, “it is the very signature of modern man to deny reality to any conception of good that imposes limits on human freedom … man’s essence is his freedom. Nothing must stand in the way of our absolute freedom to create the world as we want it. There must be no conceptions of good that put limitations on human action.” If there is no ultimate value towards which our lives point, then “the vaunted freedom of the individual to choose becomes either the necessity of finding one’s role in the public engineering or the necessity of retreating into the privacy of pleasure”. We are reduced to utilitarian measures of the good, achieved through harm reduction and happiness maximisation, materialistically defined.

The result of the liberal conception of the human person is expressive individualism, where “persons are conceived merely as atomized individual wills whose highest flourishing consists in interrogating the interior depths of the self in order to express and freely follow the original truths discovered therein toward one’s self-invented destiny”. This conception of the human person privileges cognition, will, rationality and autonomy in defining full personhood. Our nature as embodied souls is largely ignored: if one cannot employ one’s body to achieve the desires of one’s autonomous, rational, willed cognition, then one cannot achieve full personhood.

As a result, the constraints of our existential finitude made so explicit by disability are seen as immoral barriers to maximal autonomy attained through rational will. The unchosen bonds of interdependence, obligation, reciprocity and mutual loyalty that comprise the texture and meaning of life are denigrated. Liberalism discards the weak just as the Greco-Roman world once did, now done for reasons of supposed benevolence. From Locke onwards, liberalism has always seen some more capable of, and suited to, forming political society than others. Mill took this furthest in his proposal of colonisation and slavery for those less capable of freedom.

It is not such a stretch from liberalism’s definition of the individual’s capacity for personhood to advocating the killing of disabled infants deemed incapable of fulfilling this. As Leon Kass has written, it is no surprise that those Germans who coined the phrase “life unworthy of life” were two liberals: a jurist and an academic. Better to curb the depersonalised source of the suffering with all haste. James Burnham viewed liberalism as the ideological legitimator and enabler of Western suicide. I’m not sure he meant for the title of his book to be taken so literally, across so many countries.

Read it all from 2022.

Posted in Aging / the Elderly, Anthropology, Death / Burial / Funerals, Ethics / Moral Theology, Health & Medicine, Life Ethics, Theology

(BI) With AI, researchers identify a new class of antibiotic candidates

Using a type of artificial intelligence known as deep learning, MIT researchers have discovered a class of compounds that can kill a drug-resistant bacterium that causes more than 10,000 deaths in the United States every year.

In a study appearing in Nature, the researchers showed that these compounds could kill methicillin-resistant Staphylococcus aureus (MRSA) grown in a lab dish and in two mouse models of MRSA infection. The compounds also show very low toxicity against human cells, making them particularly good drug candidates.

A key innovation of the new study is that the researchers were also able to figure out what kinds of information the deep-learning model was using to make its antibiotic potency predictions. This knowledge could help researchers to design additional drugs that might work even better than the ones identified by the model.

“The insight here was that we could see what was being learned by the models to make their predictions that certain molecules would make for good antibiotics,” said James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering, a core faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University, and an institute member at the Broad Institute of MIT and Harvard. “Our work provides a framework that is time-efficient, resource-efficient, and mechanistically insightful, from a chemical-structure standpoint, in ways that we haven’t had to date.”

Read it all.

Posted in Drugs/Drug Addiction, Health & Medicine, Science & Technology

(Washington Post) On the streets, opioids sometimes more potent than fentanyl: nitazenes

A recently unsealed federal indictment in South Florida opens a rare window into the source of nitazenes: manufacturers in China that officials say sell the drugs online and ship them to dealers in the United States. Prosecutors allege that a Deerfield Beach, Fla., man used WhatsApp and bitcoin to purchase nitazenes to mix with fentanyl or heroin, to stretch out his supplies of opioids and make an “ultra powerful substance.”

“The nitazenes can make [a drug mix] stronger than fentanyl,” said Anthony Salisbury, the special agent in charge of the Homeland Security Investigations field office in South Florida. “As if we needed something stronger than fentanyl.”

The South Florida case from October included indictments against a Chinese chemical sales company and an employee of that company. According to one of the indictments, the Chinese company selling nitazenes used websites, social media accounts and messaging apps to sell chemicals such as protonitazene and metonitazene to customers in the United States, Europe, Asia and South America. As part of the investigation, a U.S. Postal Inspection Service agent posing as a buyer ordered nitazenes from the company, according to the indictment.

It was among the first criminal prosecutions to target an overseas source of nitazenes, Salisbury said.

Read it all.

Posted in China, Drugs/Drug Addiction, Health & Medicine

(Stat) In historic decision, FDA approves a CRISPR-based medicine for treatment of sickle cell disease

The Food and Drug Administration on Friday approved the world’s first medicine based on CRISPR gene-editing technology, a groundbreaking treatment for sickle cell disease that delivers a potential cure for people born with the chronic and life-shortening blood disorder.

The new medicine, called Casgevy, is made by Vertex Pharmaceuticals and CRISPR Therapeutics. Its authorization is a scientific triumph for the technology that can efficiently and precisely repair DNA mutations — ushering in a new era of genetic medicines for inherited diseases.

In a clinical trial, Casgevy was shown to eliminate recurrent episodes of debilitating pain caused by sickle cell, which afflicts approximately 100,000 people in the U.S., a vast majority of whom are Black. The therapy, whose scientific name is exa-cel, is described as a potential cure because the genetic fix enabled by CRISPR is designed to last a lifetime, although confirmation will require years of follow-up.

Read it all.

Posted in Health & Medicine, Science & Technology

(WSJ) U.S. Suicides Reached a Record High Last Year

America’s mental-health crisis drove suicides to a record-high number last year.

Nearly 50,000 people in the U.S. lost their lives to suicide in 2022, according to a provisional tally from the National Center for Health Statistics. The agency said the final count would likely be higher. The suicide rate of 14.3 deaths per 100,000 people reached its highest level since 1941.

The record reflects broad struggles to help people in mental distress following a pandemic that killed more than one million in the U.S., upended the economy and left many isolated and afraid. A shortage of healthcare workers, an increasingly toxic illicit drug supply and the ubiquity of firearms have facilitated the rise in suicides, mental-health experts said.

“There was a rupture in our economic health and social fabric. We’re still experiencing the aftereffects of that,” said Jeffrey Leichter, a psychologist who connects mental health and primary care at Sanford Health, an operator of hospitals and clinics in the Dakotas, Minnesota and Iowa.

Read it all (cited by my colleague Jonathan Bennett in his Sunday sermon).

Posted in * Culture-Watch, Anthropology, Health & Medicine, Psychology, Suicide

(NYT) Desperate Families Search for Affordable Home Care

There is precious little assistance from the government for families who need a home health aide unless they are poor. The people working in these jobs are often woefully underpaid and unprepared to help a frail, elderly person with dementia to bathe and use the bathroom, or to defuse an angry outburst.

Usually, it is family that steps into the breach — grown children who cobble together a fragile chain of visitors to help an ailing father; a middle-aged daughter who returns to her childhood bedroom; a son-in-law working from home who keeps a watchful eye on a confused parent; a wife who can barely manage herself looking after a faltering husband.

Mr. [Frank] Lee finally found two aides on his own, with no help from an agency. Using the proceeds from the sale of his stake in a group of restaurants, including the popular Charleston bistro Slightly North of Broad, he pays them the going rate of about $30 an hour. Between his wife’s care and medical expenses, he estimates that he’s spending between $80,000 and $100,000 a year.

“Who the hell can afford this?” he asked. “There’s no relief for families unless they have great wealth or see their wealth sucked away.” He worries that he will run out of money and be forced to sell their home of more than three decades. “Funds aren’t unlimited,” he said.

Read it all.

Posted in * Culture-Watch, * South Carolina, Aging / the Elderly, Children, Ethics / Moral Theology, Health & Medicine, Marriage & Family, Personal Finance & Investing

(Nature) World’s biggest set of human genome sequences opens to scientists

The world’s largest collection of full human genomes has just gone live.

The UK Biobank — a repository of health, genomic and other biological data — today released complete genome sequences from every one of the 500,000 British volunteers in the database. Researchers around the world can apply for access to the data, which lack identifiable details, and use them to probe the genetic basis for health and disease.

“Scientists are looking at this like Google Maps,” Rory Collins, the UK Biobank’s chief executive, said at a press briefing. “When they want to know what are the pathways from lifestyle, environment, genetics to disease, they don’t go Google, they go to UK Biobank.”

Today’s bonanza releases the complete 3-billion-letter genome sequence for every UK Biobank participant, and follows the 2021 release of whole genomes from 200,000 Biobank participants. The £200-million (US$250-million) effort was funded by the biomedical-research funder Wellcome, the UK government and several pharmaceutical companies — which, in return, got access to the data 9 months before their wider release.

Read it all.

Posted in Health & Medicine, Science & Technology

(Atlantic) The CRISPR Era Is Here–The much-hyped technology for editing genes has fulfilled one of its biggest promises

Four years ago, Victoria Gray joined a groundbreaking clinical trial that would change her life. She became the first sickle-cell patient to be treated with the gene-editing technology CRISPR—and one of the first humans to be treated with CRISPR, period. CRISPR at that point had largely been used only to tinker with cells in a lab. When Gray got her experimental infusion, scientists did not know whether it would cure her disease or go terribly awry inside her. The therapy worked—better than anyone dared to hope. With her gene-edited cells, Gray now lives virtually symptom-free. Twenty-nine of 30 eligible patients in the trial went from multiple pain crises every year to zero in 12 months following treatment.

The results are so astounding that this therapy, from Vertex Pharmaceuticals and CRISPR Therapeutics, became the first CRISPR medicine ever approved, with U.K. regulators giving the green light earlier this month; the FDA appears prepared to follow suit in the next two weeks. No one yet knows the long-term effects of the therapy, but today Gray is healthy enough to work full-time and take care of her four children.

Read it all.

Posted in Health & Medicine, Science & Technology

(NYT Op-ed) Darbe Saxbe–This Is Not the Way to Help Depressed Teenagers

Ever since the pandemic, when rates of teenage suicide, anxiety and depression spiked, policymakers around the world have pushed to make mental-health resources more broadly available to young people through programming in schools and on social media platforms.

This strategy is well intentioned. Traditional therapy can be expensive and time-consuming; access can be limited. By contrast, large-scale, “light touch” interventions — TikTok offerings from Harvard’s School of Public Health, grief-coping workshops in junior high — aim to reach young people where they are and at relatively low cost.

But there is now reason to think that this approach is risky. Recent studies have found that several of these programs not only failed to help young people; they also made their mental-health problems worse. Understanding why these efforts backfired can shed light on how society can — and can’t — help teenagers who are suffering from depression and anxiety.

Read it all.

Posted in Health & Medicine, Psychology, Teens / Youth

(CT) The Dangers of a Psychedelic Gospel

We have now had years of headlines talking about new research into using psychedelic drugs for therapy and, along with it, an increase in spiritual seekers.

Studies about the use of psychedelic drugs for therapy have been growing for years, with increased institutional involvement from universities, Congress, and the US Department of Defense to name just a few.

Outside of clinical trials, psychedelic use among young adults has nearly tripled in the past decade. Religious leaders—including hospital chaplains and religious psychotherapists—are also exploring the use of these drugs, as recently reported by NPR and Esquire. Ordained clergy are even conducting underground retreats that blend psychedelics with Christian worship with an emphasis on “healing.”

While I believe there are likely legitimate-use cases for psychedelic therapy that will bear out in time, I want to raise awareness of the many psychological risks of psychedelics that are often underemphasized in the research. And as a pastor, I feel an urgency to inform Christians of the serious spiritual risks of psychedelics—including the idolatry of spiritual experience.

Read it all.

Posted in Anthropology, Drugs/Drug Addiction, Ethics / Moral Theology, Health & Medicine, Religion & Culture

(Gallup) Majority Now Say U.S. Losing Ground on Illegal Drug Problem

Americans are more negative about U.S. progress in dealing with the problem of illegal drugs than at any prior point in Gallup’s trend, which dates back to 1972. For the first time, a majority of U.S. adults, 52%, say the U.S. has lost ground in coping with the illegal drug problem, while a record-low 24% say it has made progress. Another 23% believe it has stood still.

Drug overdose deaths in the U.S. have risen sharply in recent years, with much of the increase due to synthetic opioids like fentanyl. But overdoses linked to other types of drugs, including cocaine and methamphetamines, have also grown since 2019.

Gallup has updated its trend on progress in addressing the illegal drug problem periodically since the mid-1990s, after some initial measurements in the 1970s showed mixed views on the question.

Read it all.

Posted in * Culture-Watch, America/U.S.A., Drugs/Drug Addiction, Health & Medicine

([London] Times) AI tool predicts heart attacks years in advance

Thousands of lives could be saved every year by using a new artificial intelligence tool that performs better than doctors at predicting if patients will have a heart attack, a study suggests.

The technology from the University of Oxford, based on 40,000 patients in UK hospitals, can spot people with early heart problems that are missed on CT scans reviewed by the human eye.

It would mean those people could start preventive treatment, such as statins, cutting their risk of suffering or dying from a heart attack or stroke during the next decade. The AI tool is already being piloted in five UK hospitals, and researchers hope it can be rolled out further.

Read it all (registration or subscription).

Posted in Health & Medicine, Science & Technology

(Bloomberg) Half of Working-Age Americans Struggle to Afford Medical Care

Paying for health care is increasingly straining US adults as escalating medical costs converge with rising prices throughout the economy.

More than half of working-age Americans said they had difficulty paying for health care in 2023, according to a Commonwealth Fund survey published Thursday. Among people without insurance, more than three-quarters reported trouble affording care. But 43% of people with employer health plans said they had difficulty paying, and the rate was even higher among people on public health plans like Medicare and Medicaid.

The results highlight a fundamental problem in the $4.3 trillion US health system: Despite spending more on medical care than any other wealthy country, the US fails to make it broadly accessible to much of the population. The rising financial burden squeezes families and leads people to delay care, which can hurt their health over the longer term, researchers said.

“As a primary care provider I’ve seen the impact of this grow over the past several years,” said Joseph Betancourt, president of the Commonwealth Fund, a health research nonprofit. “These affordability challenges are real, they’re getting worse and they’re a clear and present danger.

Read it all (subscription).

Posted in * Economics, Politics, Economy, Health & Medicine, Personal Finance

(Tablet) Archbishop warns of mental health consequences of conflict

In his address to the conference, the Archbishop of Canterbury spoke about his own personal struggle with depression. He noted that the all-island Mind Matters research in Ireland had shown that 46 per cent of the 290 clergy surveyed felt not enough was being done to support their mental health.

He highlighted how the poverty, war and instability faced by people in the Global South contributes significantly to poor mental health while in the Global North “there is powerlessness, there is helplessness” in the face of the constant news about conflict in places like Ukraine and the Middle East and this contributed to poor mental health.

“We are better off than we have ever been in the past, yet there is a much higher level of mental illness in the economically prosperous world than elsewhere particularly among young people.”

Read it all.

Posted in --Justin Welby, Archbishop of Canterbury, Church of England, Health & Medicine, Israel, Middle East, Psychology, The Palestinian/Israeli Struggle

(Gallup) Almost a Quarter of the World Feels Lonely

Nearly one in four people worldwide — which translates into more than a billion people — feel very or fairly lonely, according to a recent Meta-Gallup survey of more than 140 countries.

Notably, these numbers could be even higher. The survey represents approximately 77% of the world’s adults because it was not asked in the second-most populous country in the world, China.

With the World Health Organization and many others — including the U.S. surgeon general — calling attention to the dangers of loneliness, these data, collected in partnership between Gallup and Meta, provide a much-needed global perspective of social wellbeing.

Read it all.

Posted in Anthropology, Globalization, Health & Medicine, Pastoral Theology, Psychology

(Premier) Church leaders considering quitting job due to stress

One in three church leaders say they want to step down from their roles within the next two years due to job-related stress, according to a new survey by Unite.

The trade union’s study revealed that 75 per cent of those surveyed regularly work beyond their contracted hours, often facing challenging situations such as providing support to individuals suffering from acute mental illness.

Rev Nicky Skipworth from Unite shared with Premier the challenging nature of the clergy’s role, emphasising the desire to be there for people in times of need but feeling they often have to rely on family and friends to feel listened to.

Read it all.

Posted in Health & Medicine, Parish Ministry, Pastoral Theology, Psychology, Stress

A Prayer for the Feast Day of Edith Cavell

Living God, who art the source of all healing and wholeness: we bless thee for the compassionate witness of thy servant Edith Cavell. Inspire us, we beseech thee, to be agents of peace and reconciliation in a world beset by injustice, poverty, and war. We ask this through Jesus Christ, the Prince of Peace, who livest and reignest with thee and the Holy Ghost, one God, unto the ages of ages. Amen.

Posted in Church History, Health & Medicine, Spirituality/Prayer

(WSJ) Is the Eye the Window to Alzheimer’s? New AI tools could diagnose the disease with visual scans

Getting tested for Alzheimer’s disease could one day be as easy as checking your eyesight.

RetiSpec has developed an artificial-intelligence algorithm that it says can analyze results from an eye scanner and detect signs of Alzheimer’s 20 years before symptoms develop. The tool is part of broader work by startups and researchers to harness AI to unlock the mysteries of a disease that afflicts more than seven million Americans.

For years, people have studied individual hallmarks of Alzheimer’s, including brain inflammation and neurodegeneration, but the exact causes of the disease remain elusive. AI, researchers say, could open a new era in the diagnosis of a neurological disease that remains difficult to identify, let alone treat.

Read it all.

Posted in Health & Medicine, Science & Technology

(Church Times) Clergy well-being: the smoke before the burnout

The social psychologist Christina Maslach has described burnout as “an erosion of the soul caused by a deterioration of one’s values, dignity, spirit, and will”.

The chief executive of the Guild of Health and St Raphael, the Revd Dr Gillian Straine, lists its symptoms: “Emotional exhaustion, loss of empathy. You want to be alone. You fantasise that you’re somewhere else. You feel unwell, pessimistic, irritable, overwhelmed. You don’t care any more.”

Burnout is common in the caring professions. But, she says, “there are certain things in the Church that make clergy more susceptible — and increase their suffering.”

She recalls a day on healing ministry organised by a diocese when five clergymen approached her to talk about depression. Two had imagined taking their own life, she says, and a third had made plans to do so.

Read it all (registration or subscription).

Posted in Church of England, Health & Medicine, Ministry of the Ordained, Parish Ministry, Psychology, Stress

(Wash. Post) An Epidemic Of Chronic Illness Is Killing Us Too Soon

The United States is failing at a fundamental mission — keeping people alive.

After decades of progress, life expectancy — long regarded as a singular benchmark of a nation’s success — peaked in 2014 at 78.9 years, then drifted downward even before the coronavirus pandemic. Among wealthy nations, the United States in recent decades went from the middle of the pack to being an outlier. And it continues to fall further and further behind.

A year-long Washington Post examination reveals that this erosion in life spans is deeper and broader than widely recognized, afflicting a far-reaching swath of the United States.

Read it all.

Posted in America/U.S.A., Health & Medicine

(TLS) Jonathan Buckley reviews Jim Down’s new book “Life in the Balance: A doctor’s stories of intensive care”

As Down says, the grey areas are what interest him most. Intensive-care guidelines are in place to ingrain the most effective procedures, and thereby reduce the stresses of decision-making in the chaos of a medical crisis. They are not infallible, however. One of Down’s patients is taken off ventilation but then dies from an “airway catastrophe”, even though the guidelines have been followed to the letter. Sometimes doctors might save a patient by deviating from the protocols, but how many more would suffer if they improvised more freely? In many cases there is not a single correct procedure to follow, and failure isn’t necessarily instructive. Good luck and bad luck play a part.

Down and his colleagues have no choice but to honour the wishes of an intelligent young patient who refuses to undergo blood transfusion on religious grounds, even though she is aware that her refusal might prove fatal. By good fortune, she pulls through. Conversely, an alcoholic patient declines rapidly and inexplicably on Down’s watch. Her symptoms suggest an abdominal collapse, but tests don’t find any evidence. Finally it is established that violent vomiting has ruptured the woman’s oesophagus, allowing acidic stomach contents to seep into her chest, lethally. The condition is known as Boerhaave syndrome, and Down berates himself for not arriving at the diagnosis sooner, even though the outcome would have been no different had the rupture been located quickly – the patient could not have survived an operation.

Read it all.

Posted in Books, Health & Medicine

(Economist) Living to 120 is becoming an imaginable prospect–Efforts to slow ageing are taking wing

Living to 100 today is not unheard of, but is still rare. In America and Britain centenarians make up around 0.03% of the population. Should the latest efforts to prolong life reach their potential, living to see your 100th birthday could become the norm; making it to 120 could become a perfectly reasonable aspiration.

More exciting still, those extra years would be healthy. What progress has been made in expanding lifespans has so far come by countering the causes of death, especially infectious disease. The process of ageing itself, with its attendant ills such as dementia, has not yet been slowed. This time, that is the intention.

The idea, as we set out in our Technology Quarterly, is to manipulate biological processes associated with ageing that, when dampened in laboratory animals, seem to extend their lives. Some of these are familiar, such as severely restricting the number of calories an animal consumes as part of an otherwise balanced diet. Living such a calorie-restricted life is too much to ask of most people; but drugs that affect the relevant biological pathways appear to bring similar results. One is metformin, which has been approved for use against type-2 diabetes; another is rapamycin, an immunosuppressant used in organ transplants. Early adopters are starting to take these drugs “off label”, off their own bat or by signing what amount to servicing contracts with a new class of longevity firms.

Read it all.

Posted in Aging / the Elderly, Health & Medicine

(Washington Post) Sitting all day increases dementia risk — even if you exercise

In news that we shouldn’t take sitting down, a study just published in JAMA finds that people who stay seated for long hours at work and home are at much higher risk of developing dementia than people who sit less.

The negative effects of extended sitting can be so strong, researchers found, that even people who exercise regularly face higher risk if they sit for much of the day.

The study, which involved 49,841 men and women aged 60 or older, “supports the idea that more time spent in sedentary behaviors increases one’s risk of dementia,” said Andrew Budson, a professor of neurology at Boston University and author of “Seven Steps to Managing Your Aging Memory,” who was not involved with the study.

The results also underscore just how pervasive the consequences of sitting can be, affecting our minds, as well as our bodies, and they hint that exercise by itself may not be enough to protect us.

Read it all.

Posted in Anthropology, Health & Medicine, Labor/Labor Unions/Labor Market

(Church Times) Anne Holmes reviews Struggling with God by Christopher C. H. Cook, Isabelle Hamley, and John Swinton

This deeply Christian book names and identifies with the holistic way in which Jesus approached people. It draws on “biblical insights, the lived experience of those who struggle with mental health challenges, the insights of psychiatry and the mental health sciences, and the resources of theology”. This makes it a vital resource for all those wishing to support those thus challenged and for those who care for and about them.

Particular features are a useful summary of specific illnesses in chapter one and close encounters with biblical narratives throughout, notably that on Job and his friends. The authors suggest that Job’s struggles were not outside God’s presence, but were “a valid and essential expression of faith in the midst of utter darkness”. This sense of despair is picked up in chapter three, in a reflection on the dark night of the soul as explored by St John of the Cross in the 16th century. Comparison is made with characteristics of a depressive disorder. The difficulty in disentangling spiritual and psychological struggles is named. This difficulty was the research object of the psychiatrist Glòria Durà-Vilà, who was troubled by the over-medicalisation of deep sadness and published her findings in Sadness, Depression, and the Dark Night of the Soul (Jessica Kingsley, 2017).

Read it all.

Posted in Anthropology, Books, Ethics / Moral Theology, Health & Medicine, Pastoral Theology, Psychology, Theology

(WashingtonPost) At Japan’s dementia cafes, forgotten orders are all part of the service

The 85-year-old server was eager to kick off his shift, welcoming customers into the restaurant with a hearty greeting: “Irasshaimase!” or “Welcome!” But when it came time to take their orders, things got a little complicated.

He walked up to a table but forgot his clipboard of order forms. He gingerly delivered a piece of cake to the wrong table. One customer waited 16 minutes for a cup of water after being seated.

But no one complained or made a fuss about it. Each time, patrons embraced his mix-ups and chuckled along with him. That’s the way it goes at the Orange Day Sengawa, also known as the Cafe of Mistaken Orders.

Read it all.

Posted in * Culture-Watch, Aging / the Elderly, Anthropology, Dieting/Food/Nutrition, Health & Medicine, Japan, Pastoral Theology

A Prayer for the Feast Day of the the Martyrs of Memphis (also called Constance and her Companions)

We give thee thanks and praise, O God of compassion, for the heroic witness of the Martyrs of Memphis, who, in a time of plague and pestilence, were steadfast in their care for the sick and dying, and loved not their own lives, even unto death; Inspire in us a like love and commitment to those in need, following the example of our Savior Jesus Christ; who with thee and the Holy Ghost liveth and reigneth, one God, now and for ever. Amen.

Posted in Church History, Health & Medicine, Spirituality/Prayer