The notion of tinkering with an embryo’s DNA – let alone creating designer babies – makes many of us recoil. But let us not forget the shock and horror at the news of the first “test-tube baby,” Louise Brown, in 1978.

After her birth, her parents received blood-spattered hate mail (and a tiny plastic fetus). Now we call it IVF, and no one bats an eye.

Technologies that allow parents to pick and choose embryos based on genetic testing are already a quarter of a century old. But the dawn of CRISPR, a technology that can “edit” mutated DNA at the embryo stage, has raised the spectre of Nazi-era eugenics and identikit babies out of a sci-fi thriller.

What if laws were in place to forbid scientists from using technologies to create the superrace we fear? What if we had consensus, and an ethical framework, to decide which embryos should live, and which should die?

Such questions are the beating heart of science journalist Bonnie Rochman’s new book, The Gene Machine: How Genetic Technologies are Changing the Way We Have Kids – and the Kids We Have, published in February.

Read it all.

Granted, reading a book that coaches you on how to reject self-help is like downing a shot of Patrón to get the nerve to stop drinking. But it appears to be working. Both “A Counterintuitive Guide to Living a Good Life,” by Mark Manson, and Sarah Knight’s “How to Stop Spending Time You Don’t Have With People You Don’t Like Doing Things You Don’t Want to Do” were best sellers. (Those are the subtitles. The titles use a pointedly vulgar phrase synonymous with “not caring one bit.”)

Now comes one of the better-written entries in the genre, “Stand Firm: Resisting the Self-Improvement Craze,” which made its author, Svend Brinkmann, a psychology professor in Denmark, a media star there.

“Our secular age is shot through with fundamental existential uncertainty and angst, and this makes it difficult to stand firm,” writes the erudite Mr. Brinkmann, who, compared with his profane and jokey American colleagues, is the Max von Sydow character in this Woody Allen movie. Mr. Brinkmann’s book, like Mr. Manson’s, takes the stand that life is hard and you’re not special, so instead of focusing on shallow quantities like happiness or success as defined by others in our culture of constant acceleration, you should acknowledge your limitations and learn to love your morning bowl of pebbles.

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As deaths from painkillers and heroin abuse spiked and street crimes increased, the mayor of Everett took major steps to tackle the opioid epidemic devastating this working-class city north of Seattle.

Mayor Ray Stephanson stepped up patrols, hired social workers to ride with officers and pushed for more permanent housing for chronically homeless people. The city says it has spent millions combating OxyContin and heroin abuse — and expects the tab to rise.

So Everett is suing Purdue Pharma, maker of the opioid pain medication OxyContin, in an unusual case that alleges the drugmaker knowingly allowed pills to be funneled into the black market and the city of about 108,000. Everett alleges the drugmaker did nothing to stop it and must pay for damages caused to the community.

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There have always been drug addicts in need of help, but the scale of the present wave of heroin and opioid abuse is unprecedented. Fifty-two thousand Americans died of overdoses in 2015—about four times as many as died from gun homicides and half again as many as died in car accidents. Pawtucket is a small place, and yet 5,400 addicts are members at Anchor. Six hundred visit every day. Rhode Island is a small place, too. It has just over a million people. One Brown University epidemiologist estimates that 20,000 of them are opioid addicts—2 percent of the population.

Salisbury, Massachusetts (pop. 8,000), was founded in 1638, and the opium crisis is the worst thing that has ever happened to it. The town lost one young person in the decade-long Vietnam War. It has lost fifteen to heroin in the last two years. Last summer, Huntington, West Virginia (pop. 49,000), saw twenty-eight overdoses in four hours. Episodes like these played a role in the decline in U.S. life expectancy in 2015. The death toll far eclipses those of all previous drug crises.

And yet, after five decades of alarm over threats that were small by comparison, politicians and the media have offered only a muted response.

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Q. What makes you think that people have become addicted to digital devices and social media?

A. In the past, we thought of addiction as mostly related to chemical substances: heroin, cocaine, nicotine. Today, we have this phenomenon of behavioral addictions where, one tech industry leader told me, people are spending nearly three hours a day tethered to their cellphones. Where teenage boys sometimes spend weeks alone in their rooms playing video games. Where Snapchat will boast that its youthful users open their app more than 18 times a day.

Behavioral addictions are really widespread now. A 2011 study suggested that 41 percent of us have at least one. That number is sure to have risen with the adoption of newer more addictive social networking platforms, tablets and smartphones.

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For people who have never questioned their birth sex, the concept of gender fluidity – which simply means that your gender identity varies – can be confusing. But in the same way that transgenderism has moved into the mainstream, thanks to the likes of Caitlyn Jenner and Laverne Cox, gender fluidity is now coming to the fore.

Hit series Billions made TV history recently by introducing television’s first gender fluid character, Taylor, played by Asia Kate Dillon. Like the on-screen character, Dillon also identifies as nonbinary, as do a plethora of high-profile names. Miley Cyrus, Jack Monroe, Angel Haze, Sting’s daughter Eliot Sumner, Tilda Swinton and Orange is the New Black star Ruby Rose have all spoken openly about feeling that their gender is not binary.

Recently, an 11-year-old actor made international headlines after being deemed eligible for an award in the male and female categories at the Leo Awards in Canada. Ameko Eks Mass Carroll starred in Limina, a short film about a non-binary child. (To be clear, non-binary refers to any gender that is not exclusively male or female.)

Read it all.

I will take comments on this submitted by email only to KSHarmon[at]mindspring[dot]com.

I shared a Helen Roseveare story last September but did not have occasion to note her passing as of yet–KSH.

Dr. Helen Roseveare, a famous English missionary to the Congo, has passed away at the age of 91.

Helen Roseveare was born in 1925 at Haileybury College (Hertfordshire, England), where her father taught mathematics.

Raised in a high Anglican church, Helen’s Sunday school teacher once told their class about India, and Helen resolved to herself that she would one day be a missionary.

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South Carolina had a larger number of cases than its neighboring states involving an increasingly popular synthetic drug that in its purest form can kill someone by just touching it.

There were 90 cases involving seized fentanyl in South Carolina in 2015, according to a recently released report by a congressional commission that monitors and investigates the national security implications of the trade and economic relationship between China and United States.

The report singled out China as the United States’ primary source of fentanyl, which was referred to as a “cheap, synthetically produced opioid” ”“ a painkiller that is about 50 times stronger than heroin and 100 times stronger than morphine.

Read more here: http://www.thestate.com/news/local/crime/article132464299.html#storylink=cpy

Read it all.

It was probably inevitable, especially on the cannabis-loving West Coast.

A Christian church has been turned into a marijuana dispensary.

The quaint building that used to house Shawnigan United Church on Vancouver Island has now been “re-christened” the Green Tree Medicinal Dispensary.

There is symbolic power in the transformation. And, depending on your tastes, the metaphorical shift is positive or negative.

Read it all.

Pensioners in Germany and Austria are suffering from delayed trauma caused by their experiences in the Second World War, resulting in assaults and threatening behaviour towards care home staff.

The problem is getting worse because the generation of children born after 1929, who were too young to fight in the war but old enough to witness its horrors, are now entering homes and hospices where suppressed memories are resurfacing, home managers and psychologists said.

Last month, an 83-year-old man pulled a pistol on two nurses in a care home in Altheim, Austria, after they found him in a corridor in his wheelchair during the night. They fled and called the police, who overpowered him. Last August, in the western German city of Münster, an 83-year-old man in a care home killed a 74-year-old man with whom he shared a room.

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From there:

“I applaud today’s moving, honest and courageous statement by Andrew Watson, the Bishop of Guildford, by making public his experience of abuse at the hands of John Smyth. The traumatic experience he and others went through is utterly appalling and punishment of this kind is wrong. In meetings with survivors of abuse, I have listened to them, prayed for them and wept with them, and am deeply conscious of their suffering. My continued prayers are with Andrew and all the victims of abuse.”

I am one of the survivors of John Smyth’s appalling activities in the late 1970s and early ’80s. I am also one of the Bishops in the Church of England. This has placed me in a unique and challenging position when it comes to the events of the past few days. My own story is certainly less traumatic than that of some others. I was drawn into the Smyth circle, as they were, and the beating I endured in the infamous garden shed was violent, excruciating and shocking; but it was thankfully a one-off experience never to be repeated. A while later one of my friends attempted suicide on the eve of another session in the shed (a story movingly told in the Channel 4 Report), and at that point I and a friend shared our story.

Read it all.

California’s millennials continue to flood hospital emergency departments because of heroin, a trend that has increased steadily statewide and in Los Angeles and Orange counties over the past five years, according to the latest figures.

The state data released last week show that in the first three months of 2016, 412 adults age 20 to 29 went to emergency departments due to heroin. That’s double the number for the same time period in 2012.

Overall, emergency department visits among heroin users of all ages increased, but the sharpest was among the state’s young adults. About 1,500 emergency department visits by California’s millennials poisoned by heroin were logged in 2015 compared with fewer than 1,000 in 2012.

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About a week later I learned that, according to the psychologist and author Harriet Lerner, the wording of my apology was just what the “doctor” would have ordered. In the very first chapter of her new book, “Why Won’t You Apologize?,” Dr. Lerner points out that apologies followed by rationalizations are “never satisfying” and can even be harmful.

“When ”˜but’ is tagged on to an apology,” she wrote, it’s an excuse that counters the sincerity of the original message. The best apologies are short and don’t include explanations that can undo them….

As to why many people find it hard to offer a sincere, unfettered apology, Dr. Lerner pointed out that “humans are hard-wired for defensiveness. It’s very difficult to take direct, unequivocal responsibility for our hurtful actions. It takes a great deal of maturity to put a relationship or another person before our need to be right.”

Read it all (my emphasis).

The British Medical Association has said pregnant women should not be called “expectant mothers” as it could offend transgender people.

Instead, they should call them “pregnant people” so as not to upset intersex and transgender men, the union has said.

The advice comes in an internal document to staff outlining a raft of common phrases that should be avoided for fear of causing offence.

Read it all.

I will take comments on this submitted by email only to KSHarmon[at]mindspring[dot]com.

Monday morning and it’s a Zumba class for the over 50s at St Stephen’s Church, Westminster. This class is part of St Stephen’s Second Half Club, a weekly day of classes that looks to build community, keep people active in mind, body and spirit, and ultimately combat social isolation. St Stephen’s is one of two London churches, the other being St Paul’s, North Marylebone running a pilot of this programme.

It is well-known that loneliness is a serious concern, with over half of adults in England saying they experience feelings of loneliness.

Although there are many different ways Anglican churches are addressing loneliness in their communities, what is truly exciting about the Second Half Clubs is the partnership that they can create with other organisations looking to achieve the same goals.

Read it all from Joseph Friedrich.

One day a week for 10 years, Stephanie Burgess made a trip to a clinic that serves the uninsured in rural Kershaw County and treated patients who might not otherwise have had access to health care.

Burgess was never paid. A clinical professor in the College of Nursing at the University of South Carolina, she went to treat the poor and enrich her students’ experience. Last year, she had to stop making the weekly trips.

State law requires Burgess to sign a contract with a supervising doctor within 45 miles of where she is practicing. But the physician who oversaw Burgess retired. While the clinic remains open, the 300 patients she saw there each year were left without access to their primary care provider….

Read it all from the local paper.

Brothers and Sisters in Christ,

On Friday morning the 20th of January, the Mall in Washington, DC, was the sight of the much-publicized Inauguration of the 45th President of the United States of America. One week later on January 27, the Mall will once again be the sight of an important event to protest prayerfully a legal decision in the United States known as Roe v. Wade from January 22, 1973. This event on the Mall will receive far less coverage than the Inauguration but is every bit as important. This year, I will make the trip to be a part of the March for Life with the contingent from Anglicans for Life and bishops from the Anglican Church in North America.

I have long protested the act of protesting. In fact, I ironically responded to the request to be a part of a “March for Jesus” in the 90’s by saying “I do not march.” Well it turns out God has other plans. So why would I leave family and home in a busy week in January? Why would I go somewhere colder than Beaufort? Simply, why march? I want to offer three main reasons:

I am marching because I am convinced that the Bible requires me to speak up for the voiceless and defenseless in our culture. No one has less power in our world than the unborn.
I am marching because I believe that the Life issue is not political but scriptural. I believe it is intrinsic to our faith, not optional.
I am marching because I want to bear witness to these truths with other Brothers and Sisters as well as other co-belligerents. I want to feel the strength of the pro-life movement in this country. Most polls show this country at about 50% pro-life but that strength is not often represented in the media.

This Sunday, we will celebrate Sanctity of Life Sunday at St. Helena’s, and there will be a bulletin insert from Anglicans for Life. I will be teaching about the sanctity of human life from a biblical perspective during the Rector’s Forum. We also will have information about the Radiance Women’s Center here in Beaufort. My hope is that many of you will feel called to join me in starting an Anglicans for Life chapter here at St. Helena’s. I believe there is much for us to do in our church and in the community to uphold the cause of life.

I look forward to seeing you on Sunday.

Blessings,

(The Rev) Shay Gaillard, rector, Saint Helena’s, Beaufort, SC

“We are the pro-life generation,” the crowd chanted, voices building to an overwhelming crescendo with each repetition of the line. Packed onto the National Mall across the street from the White House Friday, the revelers deafened one another with their joyful shouts, tens of thousands gathered just across the street from President Donald Trump’s new home, smiling and laughing and breaking into spontaneous cheers.

Such was the scene at the 44th annual March for Life, first held here on January 22, 1974, one year to the day after the Supreme Court decision in Roe v. Wade that legalized abortion nationwide. In good weather and in bad ”” given Washington’s bitter Januaries, it’s usually the latter ”” crowds swarm the Mall every year to protest against the country’s abortion laws and to advocate for the protection of unborn life.

Read it all.

#MarchForLife pic.twitter.com/JTJXmTFca6

— National Review (@NRO) January 27, 2017

Rebecca Cooper spent 27 hours on a charter bus on the Pennsylvania Turnpike last year full of teens and Christian youth leaders from West Michigan when she attended the March for Life in 2016.

Despite being stranded in two feet of snow, the then 18-year-old Michigander from Grand Rapids said their group was resilient; two members hiked across the field from the Turnpike to the home of a farmer, who then took them to a grocery store to get food. They also found creative ways to stay warm, including using prayer and song to keep them from letting the cold and confining circumstances get the best of them.

“It was an experience that made me even more devoted to attending this year’s march as opposed to discouraging me,” she said.

Read it all. You can find the website here and you can follow the twitter hashtag #marchforlife.

The isolation experienced by elderly clerics, especially in wealthy, liberal societies, is one symptom of a crisis in the Catholic priesthood. They were ordained at a time when their status as men dedicated to the church was understood and revered, sometimes to an unhealthy degree. In that era, priests could look forward an old age in which the respect and support of the faithful might compensate to some degree for the absence of any life-partner. With the standing (and finances) of the clergy damaged, in many countries, by child-abuse scandals and shabby attempts to cover them up, the twilight years are a harder prospect than ever for priests on their own, even those who have led exemplary lives. Small wonder that fewer and fewer young men want to walk the same stony path..
As measured by the number of faithful, global Catholicism is faring decently. The flock is still growing in the developing world and migration from poor countries is reinvigorating tired congregations in the West. But the priesthood, with its hard calling of celibacy, is in freefall in many places. In America, the number of Catholics connected to a parish has risen over the past half-century from 46m to 67m, while the number of priests has fallen from 59,000 to 38,000. In France, about 800 priests die every year while 100 are ordained. Priest numbers there have fallen from 29,000 in 1995 to about 15,000. On present trends they may stabilise at less than 6,000.

The result is that many jobs once done by priests, like taking funerals or ministering to the sick, are now done by lay-people or by deacons who may be married. But certain functions, including the consecration of bread and wine which is Christianity’s most important rite, can only be performed by a priest.

Read it all.

A recently released report says medical debt is the No. 1 reason consumers reported being contacted by a collection agency. If efforts to overhaul the Affordable Care Act result in more people losing their coverage, those numbers could rise.

The study by the federal Consumer Financial Protection Bureau found that 59 percent of people who reported they had been contacted by a debt collector said it was for medical services. Telecommunications bills were the second most common type of overdue bill for which debt collectors pursued payment, at 37 percent, and utilities were third, reported by 28 percent.

Unlike other types of debt, people with medical debt were prevalent across a range of income levels, credit scores and ages. A poll conducted in 2015 by NPR, The Robert Wood Johnson Foundation and Harvard’s T.H. Chan School of Public Health found that many people with health insurance still struggle to pay medical bills. Some 26 percent said health care expenses have taken a serious toll on family finances.

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It’s not often that Patriots Point Naval and Maritime Museum gets to celebrate the birthday of a pilot who actually served aboard the aircraft carrier, but today, they did just that.

Former Air Force pilot and stalwart current volunteer Bill Watkinson turned 95 on the very ship that he called home during World War II.

Watkinson, a part-time resident of Mount Pleasant, is originally from New Jersey, but he’s been a volunteer tour guide aboard the Yorktown at Patriots Point for as long as spokesman Chris Hauff can recall. “He loves the Yorktown,” Hauff said.

Read it all from the local paper.

#Veteran Bill Watkinson turned 95 today aboard the USS Yorktown where he was stationed as a pilot in #WorldWarII. https://t.co/qe0aXt6tq6 pic.twitter.com/unjOKMS8eM

— The Post and Courier (@postandcourier) January 23, 2017

The process of autophagy (literally “self-eating”) is so vital to our survival that it was the focus of the 2016 Nobel Prize in Physiology or Medicine announced in October. Winner Yoshinori Ohsumi described the discovery of this complex process as a surprise. He watched as cells wrapped entire proteins and organelles in a protective membrane””and then shredded them to pieces with enzymes. It was the equivalent of watching a wrecking ball take down a skyscraper, reducing a majestic work of architecture into a pile of bricks.

The destruction seemed counterintuitive, even dangerous. The mantra of cellular biology up to that point had been that building proteins””not destroying them””was the key to health and survival. The controlled but nonetheless devastating demolition of these structures into which so much energy and resources had been poured was perplexing. Wouldn’t this starving cell prefer to have all of its organelles””just as a body would prefer to have all of its organs? Why, in the face of adversity, would a cell demolish something it had worked very hard to build?

As Ohsumi’s team investigated further, the metaphor used for three decades changed: Autophagy isn’t cellular self-cannibalism so much as it is cellular pruning. “Organisms never waste precious resources without good reason,” Ohsumi said, “and degradation is a process essential for the creation of new life.” At its core this process was one of destruction, but it was not reckless. A cell that was indiscriminately destroying pieces of itself was not going to last long, but one that could select old, broken, misshapen, or malignant proteins and recycle them into something new would flourish.

Read it all from CT.

In the last decade alone, physicians and researchers have begun looking deeply into the impact of loneliness and social isolation on health, well being, and mortality, and the data on the subject is overwhelming: a lonely person is significantly more likely to suffer an early death than a non-lonely one.

Most of this research is centered around geriatrics, as you might guess, where feelings of loneliness are powerfully predictive of mortality. A few years ago researchers at Brigham Young University conducted an influential meta-analysis of scientific literature on the subject, and found that social isolation increases your risk of death by an astounding ~30%, and some estimates have it as high as 60%!

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It has become fashionable in recent years among some medical historians to argue that the operation was not the medical horror story that popular culture portrays it as being. These scholars suggest that, seen in the context of the times, lobotomy was perhaps a defensible response to massively overcrowded mental hospitals and the therapeutic impotence of the psychiatry of the time. That is not my view, and Luke Dittrich’s book adds to evidence from elsewhere that Scoville, like Freeman, was a monster: ambitious, driven, self-centred and willing to inflict grave and irreversible damage on his patients in his search for fame. He certainly had no time for the Hippocratic injunction, “First, do no harm”.

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College sex, it turns out, is not so very different from the hotel food in that old Jewish joke made famous by “Annie Hall”: terrible, and in such small portions.

Lisa Wade opens “American Hookup: The New Culture of Sex on Campus” with a cascade of statistics that says as much. The average graduating senior has hooked up just eight times in four years, or once per semester. Almost one-third of college students never hook up at all. Those who do report mixed feelings about the experience, with one in three saying that intimate relationships in the past year have been “traumatic” or “very difficult to handle.”

“In addition,” Ms. Wade writes, “there is a persistent malaise: a deep, indefinable disappointment.”

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Around the table at U.C.S.F., Miller stood out. The other doctors wore dress pants and button-downs ”” physician-casual ”” while he wore a sky blue corduroy shirt with a tear in the sleeve and a pair of rumpled khakis; he could have come straight from camping or Bonnaroo. Even just sitting there, he transmitted a strange charisma ”” a magnetism, people kept telling me, that was hard to explain but also necessary to explain, because the rapport Miller seems to instantly establish with everyone is a part of his gift as a clinician.

“It’s reasonable to say that it’s impossible to describe what it feels like to be with him,” [Dr. Michael] Rabow told me. “People feel accepted. I think they feel loved.”

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If the genetic basis of attributes like intelligence and musicality is too thinly spread and unclear to make selection practical, then tweaking by genetic manipulation certainly seems off the menu too. “I don’t think we are going to see superman or a split in the species any time soon,” says Greely, “because we just don’t know enough and are unlikely to for a long time ”“ or maybe for ever.”

If this is all “designer babies” could mean even in principle ”“ freedom from some specific but rare diseases, knowledge of rather trivial aspects of appearance, but only vague, probabilistic information about more general traits like health, attractiveness and intelligence ”“ will people go for it in large enough numbers to sustain an industry?

[Bioethicist Henry] Greely suspects, even if it is used at first only to avoid serious genetic diseases, we need to start thinking hard about the options we might be faced with. “Choices will be made,” he says, “and if informed people do not participate in making those choices, ignorant people will make them.”

Read it all.

Designer babies: an ethical horror waiting to happen? https://t.co/bF8Mp2dGH6

— Guardian Science (@guardianscience) January 8, 2017

James B. Johnson V’s arrest exemplifies what his attorney says is a modern “American tragedy” ”” an injury leads to painkiller addiction which, in turn, leads to heroin use.

“Local kid gets injured, gets hooked on opioids and can’t get off of them,” attorney D. Scott Lautner said Thursday. “This clearly shows the drug epidemic problem in the United States right now, that it affects everybody of different ages, sexes, religions and occupations.”

In this case, the addict is a police officer.

Read it all.